U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Apoc1 apolipoprotein C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25292, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Symbol
Apoc1provided by RGD
Full Name
apolipoprotein C1provided by RGD
Primary source
RGD:2134
See related
AllianceGenome:RGD:2134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ALPCI; LRRG04; Apo-CIB; ApoC-IB
Summary
Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Involved in regulation of lipid transport. Part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 23072.7) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Apoc1 in Genome Data Viewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88475018..88479052, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79347057..79350340, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906487.1 (10689..11406)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein E Neighboring gene translocase of outer mitochondrial membrane 40

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleotide sequence of cDNA for rat apolipoprotein C-I. Shen PY, et al. Nucleic Acids Res, 1989 Aug 11. PMID 2771655, Free PMC Article
  2. Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes. Masson D, et al. J Lipid Res, 2006 Feb. PMID 16282639
  3. Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype. Ricci F, et al. Cancer Biol Ther, 2005 Mar. PMID 15876873
  4. Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII. Hirano T, et al. Kidney Int, 2003 Jun. PMID 12753304
  5. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. Ki CS, et al. Neurosci Lett, 2002 Feb 15. PMID 11825674

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables lipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphatidylcholine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of very-low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very-low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
apolipoprotein C-I
Names
apo-CI
apoC-I
liver regeneration-related protein LRRG04

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109996.1 → NP_001103466.1  apolipoprotein C-I precursor

    See identical proteins and their annotated locations for NP_001103466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY327505, BC098670
    UniProtKB/Swiss-Prot
    P19939, Q53ZD8
    UniProtKB/TrEMBL
    A6J8R3
    Conserved Domains (1) summary
    pfam04691
    Location:27 → 86
    ApoC-I; Apolipoprotein C-I (ApoC-1)

  2. NM_012824.2 → NP_036956.1  apolipoprotein C-I precursor

    See identical proteins and their annotated locations for NP_036956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC098670, X15512
    UniProtKB/Swiss-Prot
    P19939, Q53ZD8
    UniProtKB/TrEMBL
    A6J8R3
    Conserved Domains (1) summary
    pfam04691
    Location:27 → 86
    ApoC-I; Apolipoprotein C-I (ApoC-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    88475018..88479052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281631.1 → XP_063137701.1  apolipoprotein C-I isoform X1

    UniProtKB/Swiss-Prot
    P19939, Q53ZD8
    UniProtKB/TrEMBL
    A6J8R3

  2. XM_063281630.1 → XP_063137700.1  apolipoprotein C-I isoform X1

    UniProtKB/Swiss-Prot
    P19939, Q53ZD8
    UniProtKB/TrEMBL
    A6J8R3

  3. XM_063281632.1 → XP_063137702.1  apolipoprotein C-I isoform X1

    UniProtKB/Swiss-Prot
    P19939, Q53ZD8
    UniProtKB/TrEMBL
    A6J8R3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19939.1 GenPept UniProtKB/Swiss-Prot:P19939

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous