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Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252931, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp3a18provided by RGD
Official Full Name
cytochrome P450, family 3, subfamily a, polypeptide 18provided by RGD
Primary source
RGD:628709
See related
EnsemblRapid:ENSRNOG00000000969 AllianceGenome:RGD:628709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables testosterone 16-alpha-hydroxylase activity and testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1612.2) See more
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Genomic context

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See Cyp3a18 in Genome Data Viewer
Location:
12p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13994312..14044185)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8880509..8930382)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10636294..10684273)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene uncharacterized LOC120095930 Neighboring gene ring finger protein 6 Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 8 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 73 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. Nagata K, et al. Pharmacogenetics, 1996 Feb. PMID 8845857
  2. A novel CYP3 gene from female rats. Strotkamp D, et al. Biochim Biophys Acta, 1995 Feb 21. PMID 7873612
  3. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Williams PA, et al. Science, 2004 Jul 30. PMID 15256616
  4. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. Waxman DJ, et al. Arch Biochem Biophys, 1988 Jun. PMID 3259858
  5. An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells. Jeon S, et al. Exp Mol Med, 2008 Apr 30. PMID 18446064, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables testosterone 16-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables testosterone 6-beta-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables testosterone 6-beta-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 3A18
Names
CYPIIIA18
P450(6)beta-2
cytochrome P450(6)beta-2
cytochrome P450, 3a18
NP_665725.2
XP_038945036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145782.2 → NP_665725.2  cytochrome P450 3A18

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q64581
    UniProtKB/TrEMBL
    A6K1D6, G3V635
    Related
    ENSRNOP00000001285.3, ENSRNOT00000001285.7
    Conserved Domains (1) summary
    cd20650
    Location:67 → 492
    CYP3A; cytochrome P450 family 3, subfamily A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13994312..14044185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089108.2 → XP_038945036.1  cytochrome P450 3A18 isoform X1

    Conserved Domains (1) summary
    cl41757
    Location:4 → 388
    cytochrome_P450; cytochrome P450 (CYP) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64581.1 GenPept UniProtKB/Swiss-Prot:Q64581

Gene LinkOut

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