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Hdgfl3 HDGF like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252941, updated on 2-Nov-2024

Summary

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Official Symbol
Hdgfl3provided by RGD
Official Full Name
HDGF like 3provided by RGD
Primary source
RGD:628773
See related
EnsemblRapid:ENSRNOG00000019740 AllianceGenome:RGD:628773
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hdgfrp3
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human HDGFL3 (HDGF like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 249.0), Heart (RPKM 139.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hdgfl3 in Genome Data Viewer
Location:
1q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (145233996..145287115, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135822600..135876719, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143702864..143752060, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene similar to human chromosome 15 open reading frame 40 Neighboring gene BTB domain containing 1 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene uncharacterized LOC102556513 Neighboring gene basonuclin zinc finger protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination. Kerman BE, et al. J Biol Chem, 2020 Aug 21. PMID 32647008, Free PMC Article
  2. Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons. El-Tahir HM, et al. J Biol Chem, 2009 Apr 24. PMID 19237540, Free PMC Article
  3. Expression of hepatoma-derived growth factor family members in the adult central nervous system. El-Tahir HM, et al. BMC Neurosci, 2006 Jan 23. PMID 16430771, Free PMC Article
  4. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. Ikegame K, et al. Biochem Biophys Res Commun, 1999 Dec 9. PMID 10581169
  5. Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity. Abouzied MM, et al. Biochem J, 2004 Feb 15. PMID 14572309, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
    Title: Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
  2. HRP-3 was expressed in the bulbus olfactorius, piriform cortex and amygdala complex. Expression was mainly in neurons and some brain stem oligodendrocytes.
    Title: Expression of hepatoma-derived growth factor family members in the adult central nervous system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
hepatoma-derived growth factor-related protein 3
Names
HRP-3
hepatoma-derived growth factor, related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145785.2 → NP_665728.1  hepatoma-derived growth factor-related protein 3

    See identical proteins and their annotated locations for NP_665728.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q923W4
    UniProtKB/TrEMBL
    A0A8I6A3M9
    Related
    ENSRNOP00000026754.7, ENSRNOT00000026754.9
    Conserved Domains (1) summary
    cd05834
    Location:7 → 91
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    145233996..145287115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101536.2 → XP_038957464.1  hepatoma-derived growth factor-related protein 3 isoform X2

    Related
    ENSRNOP00000086436.2, ENSRNOT00000099390.2
    Conserved Domains (1) summary
    cd05834
    Location:63 → 126
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

  2. XM_063281654.1 → XP_063137724.1  hepatoma-derived growth factor-related protein 3 isoform X4

  3. XM_063281638.1 → XP_063137708.1  hepatoma-derived growth factor-related protein 3 isoform X1

  4. XM_063281645.1 → XP_063137715.1  hepatoma-derived growth factor-related protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923W4.1 GenPept UniProtKB/Swiss-Prot:Q923W4

Gene LinkOut

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