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Saxo4 stabilizer of axonemal microtubules 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252958, updated on 2-Nov-2024

Summary

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Official Symbol
Saxo4provided by RGD
Official Full Name
stabilizer of axonemal microtubules 4provided by RGD
Primary source
RGD:708532
See related
EnsemblRapid:ENSRNOG00000020620 AllianceGenome:RGD:708532
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Iiig9; Ppp1r32
Summary
Predicted to enable phosphatase binding activity. Predicted to be involved in flagellated sperm motility. Located in cilium and cytoplasm. Orthologous to human SAXO4 (stabilizer of axonemal microtubules 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 260.0) and Lung (RPKM 18.7) See more
Orthologs
human mouse all
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Genomic context

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See Saxo4 in Genome Data Viewer
Location:
1q43
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216538735..216548195, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207113807..207122378, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226518405..226527903, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483971 Neighboring gene leucine rich repeat containing 10B Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment. Baeza V, et al. Sci Rep, 2021 Sep 17. PMID 34535732, Free PMC Article
  2. Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells. Cifuentes M, et al. Mol Neurobiol, 2018 Feb. PMID 28194645
  3. A novel mRNA expressed along brain ventricles. Danielson PE, et al. Brain Res Gene Expr Patterns, 2002 Jan. PMID 15018803
  4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
    Title: IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
  2. IIIG9 is localized in the cilia of adult ependymal cells and that its expression is correlated with the process of ependymal differentiation and with the maturation of radial glia.
    Title: Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells.
  3. IIIG9 mRNA is expressed along brain ventricles
    Title: A novel mRNA expressed along brain ventricles.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93144

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath ISO
Inferred from Sequence Orthology
more info
  
is_active_in axonemal A tubule inner sheath ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
stabilizer of axonemal microtubules 4
Names
protein phosphatase 1, regulatory subunit 32
uncharacterized protein C11orf66 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145786.1 → NP_665729.1  stabilizer of axonemal microtubules 4

    See identical proteins and their annotated locations for NP_665729.1

    Status: PROVISIONAL

    Source sequence(s)
    AY032665
    UniProtKB/Swiss-Prot
    Q66HR9, Q91XJ3, Q91XJ4
    UniProtKB/TrEMBL
    A6I033
    Related
    ENSRNOP00000028003.2, ENSRNOT00000028003.5
    Conserved Domains (1) summary
    pfam15691
    Location:2 → 416
    PPP1R32; Protein phosphatase 1 regulatory subunit 32

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216538735..216548195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281660.1 → XP_063137730.1  stabilizer of axonemal microtubules 4 isoform X1

    UniProtKB/TrEMBL
    A6I034

  2. XM_006231016.5 → XP_006231078.1  stabilizer of axonemal microtubules 4 isoform X1

    See identical proteins and their annotated locations for XP_006231078.1

    UniProtKB/Swiss-Prot
    Q66HR9, Q91XJ3, Q91XJ4
    UniProtKB/TrEMBL
    A6I033, A6I034
    Conserved Domains (1) summary
    pfam15691
    Location:1 → 372
    PPP1R32; Protein phosphatase 1 regulatory subunit 32
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HR9.1 GenPept UniProtKB/Swiss-Prot:Q66HR9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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