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Chrna7 cholinergic receptor nicotinic alpha 7 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 25302, updated on 2-Nov-2024

Summary

Official Symbol
Chrna7provided by RGD
Official Full Name
cholinergic receptor nicotinic alpha 7 subunitprovided by RGD
Primary source
RGD:2348
See related
EnsemblRapid:ENSRNOG00000010853 AllianceGenome:RGD:2348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BTX; NARAD; nAChRa7
Summary
Enables several functions, including acetylcholine binding activity; acetylcholine-gated monoatomic cation-selective channel activity; and enzyme binding activity. Involved in several processes, including neuronal action potential; regulation of ERK1 and ERK2 cascade; and synaptic signaling. Acts upstream of or within calcium ion transport and regulation of membrane potential. Located in several cellular components, including dendrite; growth cone; and plasma membrane raft. Part of acetylcholine-gated channel complex. Is active in several cellular components, including glycinergic synapse; spine apparatus membrane; and synaptic membrane. Used to study cognitive disorder. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 33.6), Brain (RPKM 22.8) and 2 other tissues See more
Orthologs
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Genomic context

See Chrna7 in Genome Data Viewer
Location:
1q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (126123425..126249181, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (116711559..116837269, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (123897341..124039263, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene non-POU domain-containing octamer-binding protein-like Neighboring gene POTE ankyrin domain family member 2 Neighboring gene F-box and WD repeat domain containing 11, pseudogene 1 Neighboring gene uncharacterized LOC102548165 Neighboring gene uncharacterized LOC102548323

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
 
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IC
Inferred by Curator
more info
PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral response to ethanol IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral response to nicotine IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite arborization IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine organization IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine organization ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of ovulation cycle rhythm IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within generation of ovulation cycle rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in memory IDA
Inferred from Direct Assay
more info
PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovulation cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to drug IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse structural plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to acetylcholine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to acetylcholine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to carbamate IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to food ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory processing IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory processing ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of acetylcholine-gated channel complex TAS
Traceable Author Statement
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axolemma IEA
Inferred from Electronic Annotation
more info
 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cholinergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cholinergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glycinergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in spine apparatus membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neuronal acetylcholine receptor subunit alpha-7
Names
C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
bungarotoxin alpha
cholinergic receptor, nicotinic, alpha 7 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 7
neuronal nicotinic acetycholine receptor alpha 7
nicotinic receptor alpha 7 subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012832.4NP_036964.3  neuronal acetylcholine receptor subunit alpha-7 precursor

    See identical proteins and their annotated locations for NP_036964.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q05941, Q53YK2
    UniProtKB/TrEMBL
    A0A0G2K5T5, A6JBJ4
    Related
    ENSRNOP00000073551.2, ENSRNOT00000082487.3
    Conserved Domains (3) summary
    TIGR00860
    Location:4490
    LIC; Cation transporter family protein
    pfam02931
    Location:26230
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:237486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    126123425..126249181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281670.1XP_063137740.1  neuronal acetylcholine receptor subunit alpha-7 isoform X1

    UniProtKB/TrEMBL
    Q5UMH9
    Related
    ENSRNOP00000045255.4, ENSRNOT00000051883.6