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Cpd carboxypeptidase D [ Rattus norvegicus (Norway rat) ]

Gene ID: 25306, updated on 2-Nov-2024

Summary

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Official Symbol
Cpdprovided by RGD
Official Full Name
carboxypeptidase Dprovided by RGD
Primary source
RGD:2393
See related
EnsemblRapid:ENSRNOG00000003873 AllianceGenome:RGD:2393
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein phosphatase 2A binding activity. Involved in cellular response to interleukin-2. Located in nucleus; perinuclear region of cytoplasm; and trans-Golgi network. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 473.7), Lung (RPKM 370.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cpd in Genome Data Viewer
Location:
10q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62121681..62185638, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (61623528..61687491, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63325764..63389811)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene golgi SNAP receptor complex member 1 Neighboring gene high mobility group nucleosome binding domain 1, pseudogene 5 Neighboring gene uncharacterized LOC134480825 Neighboring gene ribosomal protein S15, pseudogene 10 Neighboring gene uncharacterized LOC108352222 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and nuclear localization of a novel prolactin and cytokine-responsive carboxypeptidase D. Too CK, et al. Endocrinology, 2001 Mar. PMID 11181555
  2. Cloning and sequence analysis of cDNA encoding rat carboxypeptidase D. Xin X, et al. DNA Cell Biol, 1997 Jul. PMID 9260933
  3. Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. O'Malley PG, et al. Biochem J, 2005 Sep 15. PMID 15918796, Free PMC Article
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The isolation and characterization of CPD from several haematopoietic tumour cells are reported.
    Title: Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to interleukin-2 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carboxypeptidase D
Names
gp180
metallocarboxypeptidase D
NP_036968.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012836.2 → NP_036968.1  carboxypeptidase D precursor

    See identical proteins and their annotated locations for NP_036968.1

    Status: PROVISIONAL

    Source sequence(s)
    U62897
    UniProtKB/Swiss-Prot
    O35850, Q9JHW1
    UniProtKB/TrEMBL
    F1LPC6
    Related
    ENSRNOP00000005262.3, ENSRNOT00000005262.7
    Conserved Domains (4) summary
    cd03863
    Location:496 → 791
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:86 → 379
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:795 → 870
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:930 → 1208
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    62121681..62185638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHW1.2 GenPept UniProtKB/Swiss-Prot:Q9JHW1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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