Dmp1 dentin matrix acidic phosphoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dmp1provided by RGD
Official Full Name: dentin matrix acidic phosphoprotein 1provided by RGD
Primary source: RGD:2508
See related: EnsemblRapid:ENSRNOG00000002167 AllianceGenome:RGD:2508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AG1; DMP-1; DENTMAT
Summary: Enables Hsp70 protein binding activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within positive regulation of cell-substrate adhesion and regulation of enamel mineralization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular matrix. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 12.5), Heart (RPKM 8.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (5833111..5867154, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (5528441..5542078, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (6889851..6923961, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings outlined in the current study demonstrated the dental pulp protecting function of let-7c-5p during LPS-induced inflammation, which was exerted by inhibiting the DMP1-mediated NF-kappaB pathway.
Title: MicroRNA let-7c-5p Suppressed Lipopolysaccharide-Induced Dental Pulp Inflammation by Inhibiting Dentin Matrix Protein-1-Mediated Nuclear Factor kappa B (NF-κB) Pathway In Vitro and In Vivo.
Four genes are expressed significantly higher in basal bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of the proteins (SOST, MEPE, and DMP-1) are associated with mature osteocytes, indicating that basal bone has more mature osteocyte phenotypes because the immature osteocyte converts to a mature osteocyte as a result of bone mineralization.
Title: Inherent physical characteristics and gene expression differences between alveolar and basal bones.
The C-terminal Dmp1 is phosphorylated within osteocytes and then secreted into the pericanalicular matrix of mineralized bone.
Title: Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization.
bone-specific Dentin matrix protein 1overexpression changes the pattern in osteogenic gene expression pattern thereby influencing bone development
Title: Bone-specific overexpression of DMP1 influences osteogenic gene expression during endochondral and intramembranous ossification.
TCF11 may play an important role in the transcriptional regulation of Dentin matrix protein 1 gene
Title: Transcriptional regulation of dentin matrix protein 1 (DMP1) in odontoblasts and osteoblasts.
GnRH induction of Dmp1 is mediated by the protein kinase C signaling pathway.
Title: Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.
Circulating DMP1 and levels of other biochemical markers (osteocalcin, Trap5b, Dkk-1, and SOST) were measured in 2-, 4-, 8-, 12-, 18-, 24-, 72-, and 96-week-old Wistar male rats.
Title: Novel sandwich ELISAs for rat DMP1: age-related decrease of circulatory DMP1 levels in male rats.
DMP1 may play a role in reproduction as indicated by the finding in this report that the peptide GnRH, that controls FSH and LH release from the pituitary gland, causes a 600-fold induction of DMP in adult female rats. DMP1 is secreted and might act in a paracrine manner through cell-cell communication; it might also be released into the circulation and function as a hormone.
Title: Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.
The expression of DMP1 became very active from the 7th to 14th day after mandibular fracture.
Title: [Time effect of dentin matrix protein 1 and osteoclast expression during mandibular fracture healing in rats].
distinct forms of DMP1 may work collectively in controlling the mineralization process
Title: Different forms of DMP1 play distinct roles in mineralization.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of enamel mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of enamel mineralization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dentin matrix acidic phosphoprotein 1

Names: dentin matrix protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433761.1 → NP_001420690.1 dentin matrix acidic phosphoprotein 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014
NM_203493.5 → NP_987089.2 dentin matrix acidic phosphoprotein 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_987089.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P98193

UniProtKB/TrEMBL

A2VD06

Related

ENSRNOP00000095386.2, ENSRNOT00000116244.2

Conserved Domains (1) summary

pfam07263
Location:1 → 489

DMP1; Dentin matrix protein 1 (DMP1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

5833111..5867154 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272869.1 → XP_063128939.1 dentin matrix acidic phosphoprotein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6GLL4, A6K5S9
XM_006250622.5 → XP_006250684.1 dentin matrix acidic phosphoprotein 1 isoform X1

UniProtKB/Swiss-Prot

P98193

UniProtKB/TrEMBL

A0A8I6GLL4, A6K5S9

Related

ENSRNOP00000098948.1, ENSRNOT00000146800.1

Conserved Domains (2) summary

PHA02664
Location:112 → 195

PHA02664; hypothetical protein; Provisional

pfam07263
Location:1 → 504

DMP1; Dentin matrix protein 1 (DMP1)