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Emp1 epithelial membrane protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25314, updated on 2-Nov-2024

Summary

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Official Symbol
Emp1provided by RGD
Official Full Name
epithelial membrane protein 1provided by RGD
Primary source
RGD:2552
See related
EnsemblRapid:ENSRNOG00000008676 AllianceGenome:RGD:2552
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TMP; CL-20; EMP-1; ENP1MR
Summary
Predicted to be involved in apoptotic process and bleb assembly. Predicted to be active in plasma membrane. Orthologous to human EMP1 (epithelial membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 353.9), Lung (RPKM 341.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Emp1 in Genome Data Viewer
Location:
4q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169931537..169964366)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (168212901..168233039)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (169161076..169181967)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234, member B Neighboring gene germ cell associated 1 Neighboring gene phosphatidylethanolamine binding protein 2 Neighboring gene uncharacterized LOC134486686 Neighboring gene small nucleolar RNA SNORA36 family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EMP-1 is a junctional protein in a liver stem cell line and in the liver. Lee HS, et al. Biochem Biophys Res Commun, 2005 Sep 9. PMID 16036215
  2. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. Chen Y, et al. Genomics, 1997 Apr 1. PMID 9126480
  3. Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. Taylor V, et al. J Biol Chem, 1995 Dec 1. PMID 7499407
  4. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. Wilson HL, et al. J Biol Chem, 2002 Sep 13. PMID 12107182
  5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This report is the first to indicate EMP-1 to be a junctional protein in the liver.
    Title: EMP-1 is a junctional protein in a liver stem cell line and in the liver.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93627

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in bleb assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in bleb assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epithelial membrane protein 1
Names
tumor-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012843.2 → NP_036975.1  epithelial membrane protein 1

    See identical proteins and their annotated locations for NP_036975.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087031
    UniProtKB/Swiss-Prot
    P54848
    UniProtKB/TrEMBL
    A0A8I5ZRF3, A6IMG6
    Related
    ENSRNOP00000011580.3, ENSRNOT00000011580.8
    Conserved Domains (1) summary
    pfam00822
    Location:1 → 154
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    169931537..169964366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285590.1 → XP_063141660.1  epithelial membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P54848
    UniProtKB/TrEMBL
    A6IMG6

  2. XM_063285589.1 → XP_063141659.1  epithelial membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P54848
    UniProtKB/TrEMBL
    A6IMG6
    Related
    ENSRNOP00000081339.2, ENSRNOT00000118837.2

  3. XM_063285588.1 → XP_063141658.1  epithelial membrane protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P54848
    UniProtKB/TrEMBL
    A6IMG6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54848.1 GenPept UniProtKB/Swiss-Prot:P54848

Gene LinkOut

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