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Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25322, updated on 2-Nov-2024

Summary

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Official Symbol
Hsd17b1provided by RGD
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 1provided by RGD
Primary source
RGD:2836
See related
EnsemblRapid:ENSRNOG00000019830 AllianceGenome:RGD:2836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
17BHD1
Summary
Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid biosynthetic process. Predicted to be active in cytosol. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 31.2), Uterus (RPKM 23.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hsd17b1 in Genome Data Viewer
Location:
10q31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86510011..86512211)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86009728..86011928)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88987558..88989758)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit a1 Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene Coenzyme A synthase Neighboring gene PSMC3 interacting protein Neighboring gene MAX dimerization protein MLX

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Ghersevich S, et al. Endocrinology, 1994 Oct. PMID 7925110
  2. Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts. Akinola LA, et al. Gene, 1998 Feb 27. PMID 9524272
  3. 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Suzuki T, et al. Br J Cancer, 2000 Feb. PMID 10682658, Free PMC Article
  4. Reaction mechanism of 17-beta-estradiol dehydrogenase determined by equilibrium rate exchange. Betz G. J Biol Chem, 1971 Apr 10. PMID 4396689
  5. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola LA, et al. Endocrinology, 1996 May. PMID 8612487

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
    Title: Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables NADP+ binding ISO
Inferred from Sequence Orthology
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables estradiol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
enables testosterone dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables testosterone dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in bone development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to metal ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in estrogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in estrogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in estrogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in testosterone biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
estradiol 17-beta-dehydrogenase 1
Names
17-beta-HSD 1
17-beta-hydroxysteroid dehydrogenase type 1
Hydroxysteroid dehydrogenase 17 beta, type 1
NP_036983.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012851.2 → NP_036983.1  estradiol 17-beta-dehydrogenase 1

    See identical proteins and their annotated locations for NP_036983.1

    Status: PROVISIONAL

    Source sequence(s)
    X97754
    UniProtKB/Swiss-Prot
    P51657
    UniProtKB/TrEMBL
    A6HJ77
    Related
    ENSRNOP00000026878.5, ENSRNOT00000026878.7
    Conserved Domains (1) summary
    cl21454
    Location:4 → 260
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86510011..86512211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51657.1 GenPept UniProtKB/Swiss-Prot:P51657

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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