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sum3 translation initiation RNA helicase Sum3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538689, updated on 14-Nov-2024

Summary

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Official Symbol
sum3
Official Full Name
translation initiation RNA helicase Sum3
Primary source
PomBase:SPCC1795.11
Locus tag
SPOM_SPCC1795.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ded1; moc2; slh3
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Genomic context

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See sum3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (973999..976713, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein SVP26 Neighboring gene yapsin Yps1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe. Kawamukai M. Biochim Biophys Acta, 1999 Jul 7. PMID 10395922
  2. Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis. Epling LB, et al. J Mol Biol, 2015 May 8. PMID 25724843, Free PMC Article
  3. The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization. Yan KK, et al. Nucleic Acids Res, 2021 Aug 20. PMID 34302476, Free PMC Article
  4. The Ded1 DEAD box helicase interacts with Chk1 and Cdc2. Liu HY, et al. J Biol Chem, 2002 Jan 25. PMID 11711540
  5. A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. Grallert B, et al. J Cell Sci, 2000 Apr. PMID 10725227

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization.
    Title: The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization.
  2. Overexpression of Moc1, Moc2, Moc3, Moc4 and Rpl32-2 resulted in the efficient induction of a key transcription factor Ste11.
    Title: A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation EXP
Inferred from Experiment
more info
 PubMed 
involved_in cytoplasmic translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translational initiation in response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation initiation RNA helicase Sum3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    973999..976713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023025.3 → NP_588033.1  translation initiation RNA helicase Sum3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588033.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13370, O59857, Q9UU14
    Conserved Domains (3) summary
    cd00079
    Location:403 → 533
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:171 → 393
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:68 → 568
    PTZ00110; helicase; Provisional
Nucleotide Protein
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