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bio2 biotin synthase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538717, updated on 18-Sep-2024

Summary

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Official Symbol
bio2
Official Full Name
biotin synthase
Primary source
PomBase:SPCC1235.02
Locus tag
SPOM_SPCC1235.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPCC320.01c
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Genomic context

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See bio2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (176817..178818)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene SMR domain-containing protein Neighboring gene ncRNA Neighboring gene FAD synthetase Nad1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of Schizosaccharomyces pombe bio2 by heterologous complementation of a Saccharomyces cerevisiae mutant. Phalip V, et al. Curr Microbiol, 1999 Dec. PMID 10525840
  2. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article
  3. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
  4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables biotin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables biotin synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
biotin synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    176817..178818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022723.3 → NP_587728.1  biotin synthase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587728.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59778, O60050
    Conserved Domains (3) summary
    cd01335
    Location:66 → 268
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    COG0502
    Location:20 → 345
    BioB; Biotin synthase or related enzyme [Coenzyme transport and metabolism]
    pfam06968
    Location:242 → 329
    BATS; Biotin and Thiamin Synthesis associated domain
Nucleotide Protein
Heading Accession and Version

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