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ura4 orotidine 5'-phosphate decarboxylase Ura4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538768, updated on 18-Sep-2024

Summary

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Official Symbol
ura4
Official Full Name
orotidine 5'-phosphate decarboxylase Ura4
Primary source
PomBase:SPCC330.05c
Locus tag
SPOM_SPCC330.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ura4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (115589..116625, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein tam14 Neighboring gene protein new25 Neighboring gene ncRNA Neighboring gene thioredoxin-related chaperone Pmp20

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and expression of the OMP decarboxylase gene URA4 from Schizosaccharomyces pombe. Bach ML. Curr Genet, 1987. PMID 2834100
  2. Urea enhances cell lysis of Schizosaccharomyces pombe ura4 mutants. Nishino K, et al. Biosci Biotechnol Biochem, 2017 Jul. PMID 28345447
  3. Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4. Nishino K, et al. PLoS One, 2015. PMID 26536126, Free PMC Article
  4. Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast. Matsuo Y, et al. PLoS One, 2013. PMID 23555823, Free PMC Article
  5. Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes. Kohda TA, et al. Genes Cells, 2007 Feb. PMID 17295836

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Urea enhances cell lysis of Schizosaccharomyces pombe ura4 mutants.
    Title: Urea enhances cell lysis of Schizosaccharomyces pombe ura4 mutants.
  2. Ura4 was predominantly localized at the membrane, uracil uptake increased and cell lysis was suppressed.
    Title: Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.
  3. ura4 deletion mutant S. pombe cells are lysed by polypeptone
    Title: Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables orotidine-5'-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotidine-5'-phosphate decarboxylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables orotidine-5'-phosphate decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in protein aggregate center IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
orotidine 5'-phosphate decarboxylase Ura4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    115589..116625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022700.3 → NP_587705.1  orotidine 5'-phosphate decarboxylase Ura4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587705.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P14965
    Conserved Domains (1) summary
    pfam00215
    Location:33 → 249
    OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
Nucleotide Protein
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