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hst2 histone deacetylase, Sirtuin family, NAD-dependent Hst2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538868, updated on 18-Sep-2024

Summary

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Official Symbol
hst2
Official Full Name
histone deacetylase, Sirtuin family, NAD-dependent Hst2
Primary source
PomBase:SPCC132.02
Locus tag
SPOM_SPCC132.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See hst2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003421.2 (1328952..1330790)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene prohibitin Phb2 Neighboring gene ncRNA Neighboring gene ribosome quality control complex subunit Rqc2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global analysis of gel mobility of proteins and its use in target identification. Shirai A, et al. J Biol Chem, 2008 Apr 18. PMID 18292091
  2. Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing. Durand-Dubief M, et al. EMBO J, 2007 May 16. PMID 17446861, Free PMC Article
  3. Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA. Nakamura T, et al. Open Biol, 2012 Sep. PMID 23091701, Free PMC Article
  4. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038
  5. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD-dependent histone H3K9 deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein lysine deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase, Sirtuin family, NAD-dependent Hst2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1328952..1330790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023136.3 → NP_588147.1  histone deacetylase, Sirtuin family, NAD-dependent Hst2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588147.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9USN7
    Conserved Domains (1) summary
    cd01408
    Location:28 → 262
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
Nucleotide Protein
Heading Accession and Version

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