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ssp1 calcium/calmodulin-dependent (CaMKK) protein kinase Ssp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538951, updated on 18-Sep-2024

Summary

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Official Symbol
ssp1
Official Full Name
calcium/calmodulin-dependent (CaMKK) protein kinase Ssp1
Primary source
PomBase:SPCC297.03
Locus tag
SPOM_SPCC297.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ssp1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1878447..1882310)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor, CBF1/Su(H)/LAG-1 family Cbf12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chorismate synthase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene diacylglycerol-binding protein Neighboring gene histone lysine methyltransferase Set7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress. Schutt KL, et al. Mol Biol Cell, 2017 Jul 1. PMID 28515144, Free PMC Article
  2. Genetic and physical interaction of Ssp1 CaMKK and Rad24 14-3-3 during low pH and osmotic stress in fission yeast. Freitag SI, et al. Open Biol, 2014 Jan 22. PMID 24451546, Free PMC Article
  3. Nitrogen regulates AMPK to control TORC1 signaling. Davie E, et al. Curr Biol, 2015 Feb 16. PMID 25639242, Free PMC Article
  4. AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. Valbuena N, et al. J Cell Sci, 2012 Jun 1. PMID 22375066
  5. Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe. Gómez-Hierro A, et al. PLoS One, 2015. PMID 26575035, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ssp1 promotes cell polarity by phosphorylating the activation loop of the MARK/PAR-1 family kinase Kin1. Additional Kin1 substrates for cell polarity and cytokinesis were also phosphorylated by the DYRK family member Pom1.
    Title: Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
  2. Ssp1 connects the network of components that ensures proper polarity and cell size with the network of proteins that regulates Cdk1-cyclin B activity, in which Srk1 plays an inhibitory role.
    Title: Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe.
  3. Ssp1 is required for long-term cell survival under hyperosmotic conditions.
    Title: Genetic and physical interaction of Ssp1 CaMKK and Rad24 14-3-3 during low pH and osmotic stress in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables calcium/calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade IC
Inferred by Curator
more info
  
involved_in cell growth mode switching, monopolar to bipolar IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in induction of conjugation with cellular fusion EXP
Inferred from Experiment
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell cycle switching, mitotic to meiotic cell cycle EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex of growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 

General protein information

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Preferred Names
calcium/calmodulin-dependent (CaMKK) protein kinase Ssp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1878447..1882310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023351.3 → NP_588360.1  calcium/calmodulin-dependent (CaMKK) protein kinase Ssp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588360.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P50526, Q9UTZ4
    Conserved Domains (2) summary
    smart00220
    Location:135 → 408
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14008
    Location:141 → 409
    STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins
Nucleotide Protein
Heading Accession and Version

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