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pca1 metacaspase Pca1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538976, updated on 18-Sep-2024

Summary

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Official Symbol
pca1
Official Full Name
metacaspase Pca1
Primary source
PomBase:SPCC1840.04
Locus tag
SPOM_SPCC1840.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pca1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003421.2 (2263967..2267305)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene karyopherin/importin beta family nuclear import signal receptor Sal3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phosphoglucomutase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F0-ATPase delta subunit atp5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe). Agus HH, et al. FEMS Yeast Res, 2020 Jun 1. PMID 32347926
  2. Overexpression of a metacaspase gene stimulates cell growth and stress response in Schizosaccharomyces pombe. Lim HW, et al. Can J Microbiol, 2007 Aug. PMID 17898859
  3. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
  4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe).
    Title: Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
metacaspase Pca1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2263967..2267305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023493.3 → NP_588503.1  metacaspase Pca1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588503.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74477
    Conserved Domains (3) summary
    pfam00656
    Location:130 → 421
    Peptidase_C14; Caspase domain
    pfam12273
    Location:2 → 86
    RCR; Chitin synthesis regulation, resistance to Congo red
    pfam15240
    Location:22 → 120
    Pro-rich; Proline-rich
Nucleotide Protein
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