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dus4 tRNA dihydrouridine synthase Dus4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538996, updated on 18-Sep-2024

Summary

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Official Symbol
dus4
Official Full Name
tRNA dihydrouridine synthase Dus4
Primary source
PomBase:SPCC777.15
Locus tag
SPOM_SPCC777.15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See dus4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1624649..1626267)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retromer complex subunit Vps35 Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Prp4 Neighboring gene protein phosphatase regulatory subunit Ekc1 Neighboring gene ncRNA Neighboring gene wtf element Wtf14 Neighboring gene wtf element Wtf15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Finet O, et al. Mol Cell, 2022 Jan 20. PMID 34798057, Free PMC Article
  2. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
  3. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
  4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
  5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-dihydrouridine20a synthase activity EXP
Inferred from Experiment
more info
 PubMed 
enables tRNA-dihydrouridine20b synthase activity EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
tRNA dihydrouridine synthase Dus4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1624649..1626267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023252.3 → NP_588262.1  tRNA dihydrouridine synthase Dus4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588262.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74553
    Conserved Domains (2) summary
    COG0042
    Location:19 → 303
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:23 → 250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
Nucleotide Protein
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