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hmg1 3-hydroxy-3-methylglutaryl-CoA reductase Hmg1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538999, updated on 22-Jun-2024

Summary

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Gene symbol
hmg1
Gene description
3-hydroxy-3-methylglutaryl-CoA reductase Hmg1
Locus tag
SPOM_SPCC162.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
its12
Old locus tag
SPCC162.09c
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Genomic context

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See hmg1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1561215..1565491)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uridine kinase/uracil phosphoribosyltransferase Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleoporin nup211 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors. Argüelles N, et al. Bioorg Med Chem, 2010 Jun 15. PMID 20576575
  2. Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis. Imagawa K, et al. Kobe J Med Sci, 2009 Jun 5. PMID 20847589
  3. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Burg JS, et al. Cell Metab, 2008 Dec. PMID 19041767, Free PMC Article
  4. Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast. Burg JS, et al. J Biol Chem, 2011 Aug 5. PMID 21680738, Free PMC Article
  5. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, et al. EMBO J, 2005 Nov 16. PMID 16270032, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This is the first demonstration of clear phenotypes arising from a nonsense mutation of an essential gene, HMG1, in fission yeast.
    Title: Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.
  2. Intracellular Signaling Peptides and Proteins dependent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase activity functions through the phosphorylation of S1024 and T1028.
    Title: Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sterol sensor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3-hydroxy-3-methylglutaryl-CoA reductase Hmg1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1561215..1565491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023225.3 → NP_588235.1  3-hydroxy-3-methylglutaryl-CoA reductase Hmg1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588235.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74425, Q10283
    Conserved Domains (3) summary
    cd00643
    Location:617 → 1023
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    pfam13323
    Location:4 → 30
    HPIH; N-terminal domain with HPIH motif
    cl21543
    Location:231 → 371
    MMPL; MMPL family
Nucleotide Protein
Heading Accession and Version

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