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lig4 DNA repair ligase Lig4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539042, updated on 18-Sep-2024

Summary

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Official Symbol
lig4
Official Full Name
DNA repair ligase Lig4
Primary source
PomBase:SPCC1183.05c
Locus tag
SPOM_SPCC1183.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See lig4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003421.2 (599420..602916, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene frataxin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA metabolism pathway protein Pet127 Neighboring gene ncRNA Neighboring gene uracil DNA N-glycosylase Ung1 Neighboring gene ncRNA Neighboring gene protein Spo13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide screens for sensitivity to ionizing radiation identify the fission yeast nonhomologous end joining factor Xrc4. Li J, et al. G3 (Bethesda), 2014 May 21. PMID 24847916, Free PMC Article
  2. The telomere bouquet controls the meiotic spindle. Tomita K, et al. Cell, 2007 Jul 13. PMID 17632059
  3. The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Ferreira MG, et al. Mol Cell, 2001 Jan. PMID 11172711
  4. Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast. Manjón E, et al. Nucleic Acids Res, 2017 May 19. PMID 28334931, Free PMC Article
  5. The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair. Reis CC, et al. EMBO J, 2012 Dec 12. PMID 23188080, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA ligase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via classical nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA ligase IV complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA ligase IV complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA repair ligase Lig4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    599420..602916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022880.3 → NP_587888.2  DNA repair ligase Lig4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587888.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74833
    Conserved Domains (4) summary
    cd07968
    Location:470 → 611
    OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
    cd07903
    Location:242 → 467
    Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
    TIGR00574
    Location:89 → 613
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    pfam04675
    Location:20 → 207
    DNA_ligase_A_N; DNA ligase N terminus
Nucleotide Protein
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