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tea1 cell end marker Tea1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539047, updated on 18-Sep-2024

Summary

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Official Symbol
tea1
Official Full Name
cell end marker Tea1
Primary source
PomBase:SPCC1223.06
Locus tag
SPOM_SPCC1223.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
alp8
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Genomic context

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See tea1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1848771..1852620)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DASH complex subunit Spc19 Neighboring gene 60S ribosomal protein eL37 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene aspartate--tRNA (Asp) ligase Drs1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell. Mata J, et al. Cell, 1997 Jun 13. PMID 9200612
  2. Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton. Behrens R, et al. J Cell Biol, 2002 May 27. PMID 12034771, Free PMC Article
  3. Robust polarity specification operates above a threshold of microtubule dynamicity. Thadani R, et al. Cytoskeleton (Hoboken), 2011 May. PMID 21548112
  4. Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast. Browning H, et al. J Cell Biol, 2000 Oct 2. PMID 11018050, Free PMC Article
  5. Role of bud6p and tea1p in the interaction between actin and microtubules for the establishment of cell polarity in fission yeast. Glynn JM, et al. Curr Biol, 2001 Jun 5. PMID 11516644

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study proposes that Cki3 monitors the timing of growth polarity transition from monopolar to bipolar during G2 phase onset through Tea1 phosphorylation by regulating the interaction between Tea1 and Tea4.
    Title: Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.
  2. Study constructed fission yeast strains exhibiting depressed microtubule dynamics by mutating the beta-tubulin gene, nda3. This interfered with efficient accumulation of a polarity factor Tea1 at cell tips.
    Title: Robust polarity specification operates above a threshold of microtubule dynamicity.
  3. Data suggest that rather than acting simply as a Tea1 receptor or as a molecular "glue" to retain Tea1, Mod5 functions catalytically to stimulate incorporation of Tea1 into a stable tip-associated cluster network.
    Title: A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark.
  4. nuclear centering becomes essential when Pom1/Tea1/Tea4 function is compromised and that Kin1 expression level is a key regulatory element in this situation
    Title: Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast.
  5. results suggest that independent protein-protein interactions among tea1p, tea3p and mod5p collectively contribute to tea1p anchoring at cell tips via a multistep and multimode mechanism
    Title: Multistep and multimode cortical anchoring of tea1p at cell tips in fission yeast.
  6. End4/Sla2 acts downstream of the polarity marker Tea1 and is implicated in the recruitment of the actin cytoskeleton to bring about polarised cell growth
    Title: End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment or maintenance of bipolar cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of bipolar cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment or maintenance of bipolar cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to cell cortex of cell tip IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex of cell tip IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytoplasmic microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
NOT is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton HDA PubMed 
is_active_in microtubule end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in non-growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in old growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in static microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell end marker Tea1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1848771..1852620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023342.3 → NP_588351.1  cell end marker Tea1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588351.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P87061
    Conserved Domains (8) summary
    COG0419
    Location:594 → 1121
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    sd00038
    Location:188 → 239
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:242 → 287
    Kelch_1; Kelch motif
    pfam07646
    Location:187 → 236
    Kelch_2; Kelch motif
    pfam13415
    Location:92 → 142
    Kelch_3; Galactose oxidase, central domain
    pfam13418
    Location:292 → 338
    Kelch_4; Galactose oxidase, central domain
    cl21478
    Location:608 → 726
    ATP-synt_B; ATP synthase B/B' CF(0)
    cl23720
    Location:866 → 952
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version

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