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rik1 CLRC ubiquitin ligase complex WD repeat protein Rik1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539050, updated on 18-Sep-2024

Summary

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Official Symbol
rik1
Official Full Name
CLRC ubiquitin ligase complex WD repeat protein Rik1
Primary source
PomBase:SPCC11E10.08
Locus tag
SPOM_SPCC11E10.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rik1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1467882..1471912)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene translation initiation factor eIF2B alpha subunit Gcn3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-amylase-like protein Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast heterochromatin protein Rik1 is required for telomere clustering during meiosis. Tuzon CT, et al. J Cell Biol, 2004 Jun 21. PMID 15197176, Free PMC Article
  2. Distinct centromere domain structures with separate functions demonstrated in live fission yeast cells. Appelgren H, et al. J Cell Sci, 2003 Oct 1. PMID 12928332
  3. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Jia S, et al. Nat Cell Biol, 2005 Oct. PMID 16127433
  4. Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast. Yu Y, et al. Sci Rep, 2016 Aug 19. PMID 27538348, Free PMC Article
  5. Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Zhang K, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18345014

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. characterization of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon) [Dos2 & Rik1]
    Title: Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.
  2. Thus the association of a DCAF, Raf1, with its adaptor, Rik1, is required for histone methylation and to allow RNAi to signal to chromatin
    Title: Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.
  3. Components of the Clr4 histone K3-K9 methyltransferase-Rik1-Cullin4 complex act concertedly at an early step in heterochromatin formation.
    Title: A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic telomere tethering at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in pericentric heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in siRNA-mediated heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in subtelomeric heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
NOT involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CLRC complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in subtelomeric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CLRC ubiquitin ligase complex WD repeat protein Rik1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1467882..1471912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023194.3 → NP_588204.1  CLRC ubiquitin ligase complex WD repeat protein Rik1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588204.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10426, Q9USN9, Q9UUL7
    Conserved Domains (2) summary
    pfam03178
    Location:712 → 999
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:73 → 512
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
Nucleotide Protein
Heading Accession and Version

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