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gcs2 glutamate-cysteine ligase regulatory subunit Gcs2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539059, updated on 18-Sep-2024

Summary

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Official Symbol
gcs2
Official Full Name
glutamate-cysteine ligase regulatory subunit Gcs2
Primary source
PomBase:SPCC737.06c
Locus tag
SPOM_SPCC737.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See gcs2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003421.2 (1895954..1897546, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene peroxin Pex28/29 Neighboring gene DNA polymerase alpha-associated DNA helicase A Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene midasin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article
  2. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
  3. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
  4. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables glutamate-cysteine ligase catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-cysteine ligase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-cysteine ligase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification NAS
Non-traceable Author Statement
more info
  
involved_in cysteine metabolic process IC
Inferred by Curator
more info
  
involved_in glutathione biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of glutamate-cysteine ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutamate-cysteine ligase regulatory subunit Gcs2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1895954..1897546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023359.3 → NP_588368.1  glutamate-cysteine ligase regulatory subunit Gcs2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588368.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94246
    Conserved Domains (1) summary
    COG0656
    Location:4 → 283
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein
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