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pku70 Ku domain protein Pku70 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539090, updated on 18-Sep-2024

Summary

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Official Symbol
pku70
Official Full Name
Ku domain protein Pku70
Primary source
PomBase:SPCC126.02c
Locus tag
SPOM_SPCC126.02C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ku70
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Genomic context

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See pku70 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003421.2 (2117095..2119663, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA/U2 snRNA pseudouridine synthase Lsp1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination. Decottignies A. Genetics, 2007 Jul. PMID 17483423, Free PMC Article
  2. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. Manolis KG, et al. EMBO J, 2001 Jan 15. PMID 11226171, Free PMC Article
  3. Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double-strand break. Li T, et al. Genetics, 2021 May 17. PMID 33723569, Free PMC Article
  4. Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. Miyoshi T, et al. J Biol Chem, 2003 Jan 17. PMID 12424244
  5. Protection of telomeres by the Ku protein in fission yeast. Baumann P, et al. Mol Biol Cell, 2000 Oct. PMID 11029034, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest the possibility that Ku proteins (pku70, pku80)play an important role in genome integrity recovering replication stress.
    Title: Fission yeast Ku protein is required for recovery from DNA replication stress.
  2. potential relevance of Bin1-Ku interaction to cancer are discussed in light of these findings
    Title: Bin1 interacts with and restrains the DNA end-binding protein complex Ku.
  3. Pku70 inhibited microhomology-mediated end-joining and increased the minimal homology length required for efficient microhomology-mediated end-joining
    Title: Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stalled replication fork localization to nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ku70:Ku80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ku domain protein Pku70
NP_001342782.1
  • Ku70 (human XRCC6 ortholog) Pku70

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2117095..2119663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355945.2 → NP_001342782.1  Ku domain protein Pku70 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94395
    Conserved Domains (2) summary
    cd00788
    Location:234 → 514
    KU70; Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
    cl25384
    Location:16 → 605
    Ku_C; Ku70/Ku80 C-terminal arm
Nucleotide Protein
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Gene LinkOut

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Molecular Biology Databases
Research Materials