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brl1 histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539102, updated on 18-Sep-2024

Summary

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Official Symbol
brl1
Official Full Name
histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl1
Primary source
PomBase:SPCC1919.15
Locus tag
SPOM_SPCC1919.15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rfp2; SPCC790.01
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Genomic context

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See brl1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (2239847..2242154)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene rRNA (uridine-N3-)-methyltransferase Bmt5 Neighboring gene transcription factor TFIIIB complex subunit Bdp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase E3 Neighboring gene Golgi rhomboid protease Rbd2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Tanny JC, et al. Genes Dev, 2007 Apr 1. PMID 17374714, Free PMC Article
  2. HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast. Zofall M, et al. J Biol Chem, 2007 May 11. PMID 17363370
  3. The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1. Flury V, et al. Mol Cell, 2017 Jul 20. PMID 28648780, Free PMC Article
  4. Fission yeast Rnf4 homologs are required for DNA repair. Kosoy A, et al. J Biol Chem, 2007 Jul 13. PMID 17502373
  5. Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe. Elmore ZC, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948786, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H2B C-terminal K residue ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation-coupled chromatin remodeling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2239847..2242154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023487.3 → NP_588497.1  histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588497.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q1MTQ0
    Conserved Domains (3) summary
    cd00162
    Location:638 → 682
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam08647
    Location:446 → 540
    BRE1; BRE1 E3 ubiquitin ligase
    pfam12777
    Location:227 → 315
    MT; Microtubule-binding stalk of dynein motor
Nucleotide Protein
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