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nmt1 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Nmt1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539108, updated on 22-Jun-2024

Summary

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Gene symbol
nmt1
Gene description
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Nmt1
Locus tag
SPOM_SPCC1223.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
thi3
Old locus tag
SPCC1223.02
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Genomic context

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See nmt1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1838415..1839664)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glycerol-3-phosphate dehydrogenase Gut2 Neighboring gene tRNA-His

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation. Rojas DA, et al. Genes (Basel), 2022 Jan 28. PMID 35205301, Free PMC Article
  2. Amiloride toxicity in the fission yeast Schizosaccharomyces pombe is released by thiamine and mutations in the thiamine-repressible gene car1. Niederberger C, et al. Gene, 1996 May 24. PMID 8675019
  3. Joint regulation of the nmt1 promoter and sporulation by Thi1 and Thi5 in Schizosaccharomyces pombe. McQuire TA, et al. Curr Genet, 2006 Oct. PMID 16874521
  4. The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. Fontebasso Y, et al. DNA Repair (Amst), 2013 Dec. PMID 24192486, Free PMC Article
  5. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation.
    Title: Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation.
  2. nmt1 promoter is regulatd by Thi1 and Thi5.
    Title: Joint regulation of the nmt1 promoter and sporulation by Thi1 and Thi5 in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in thiamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Nmt1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1838415..1839664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023338.3 → NP_588347.1  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Nmt1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588347.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36597
    Conserved Domains (2) summary
    cd13650
    Location:5 → 254
    PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily
    pfam09084
    Location:16 → 236
    NMT1; NMT1/THI5 like
Nucleotide Protein
Heading Accession and Version

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