wee1 protein kinase Wee1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Go to the top of the page Help

Official Symbol: wee1
Official Full Name: protein kinase Wee1
Primary source: PomBase:SPCC18B5.03
Locus tag: SPOM_SPCC18B5.03
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See wee1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_003421.2 (721804..725835)

Chromosome III - NC_003421.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.
Title: Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.
Authors propose a two-step model for inhibition of Wee1 by Cdr1 and Cdr2 at nodes.
Title: A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.
Regulation of Wee1 localization around the spindle pole body during the G2/M transition is important for proper mitotic entry and progression.
Title: Spatiotemporal regulations of Wee1 at the G2/M transition.
in fission yeast Wee1 is the major inhibitory kinase regulating CDK activity in S phase.
Title: Consequences of abnormal CDK activity in S phase.
This cell cycle arrest is dependent on the Wee1 tyrosine kinase inhibiting the key cell cycle regulator, CDK1/Cdc2. Mutant cells lacking Wee1 are not arrested at G2 upon glucose limitation and lose viability faster than the wild-type cells under glucose-depleted quiescent conditions, suggesting that this cell cycle arrest is required for extension of chronological lifespan
Title: Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan.
Wee1 phosphorylates Cdc2 Tyr15 which leads to replication slowdown in the fission yeast under nitrosative stress.
Title: Nitrosative stress induces a novel intra-S checkpoint pathway in Schizosaccharomyces pombe involving phosphorylation of Cdc2 by Wee1.
Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.
Title: Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.
Substitution of a conserved methionine residue to phenylalanine in Plo1, Orb5 and Wee1 kinases increased the sensitivities to ATP analogues.
Title: Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
Data show that the protein Skb1 interacted with both Cdr1 and the Cdr1 inhibitory target Wee1.
Title: Compartmentalized nodes control mitotic entry signaling in fission yeast.
Sid2 activation midway through G2 phase promotes Fin1 phosphorylation and mitotic commitment throught pom1/Wee1 cell geometry network.
Title: The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic DNA damage checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in mitotic G1 cell size control checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 cell size control checkpoint signaling	EXP Inferred from Experiment more info	PubMed
involved_in mitotic G2 cell size control checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	EXP Inferred from Experiment more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	EXP Inferred from Experiment more info	PubMed

Component	Evidence Code	Pubs
part_of Cdr2 medial cortical node complex	EXP Inferred from Experiment more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in medial cortical node	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	HDA more info	PubMed
is_active_in mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein kinase Wee1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003421.2 Reference assembly

Range

721804..725835

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022924.3 → NP_587933.1 protein kinase Wee1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_587933.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P07527, Q9UU00

Conserved Domains (2) summary

cd14052
Location:565 → 838

PTKc_Wee1_fungi; Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins

pfam00069
Location:566 → 836

Pkinase; Protein kinase domain