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hnt3 aprataxin-like protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539198, updated on 18-Sep-2024

Summary

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Official Symbol
hnt3
Official Full Name
aprataxin-like protein
Primary source
PomBase:SPCC18.09c
Locus tag
SPOM_SPCC18.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
aptx
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Genomic context

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See hnt3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1970754..1973820, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase III complex subunit Rpc53 Neighboring gene lysine--tRNA (Lys) ligase Neighboring gene ncRNA Neighboring gene pyridoxine-pyridoxal-pyridoxamine kinase Neighboring gene Set1C complex and Lid2 complex subunit, Dpy-30 domain Sdc1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Chauleau M, et al. Nucleic Acids Res, 2015 Jul 13. PMID 26007660, Free PMC Article
  2. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Gong Y, et al. Nat Struct Mol Biol, 2011 Oct 9. PMID 21984208
  3. Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease. Tumbale P, et al. Nat Struct Mol Biol, 2011 Oct 9. PMID 21984210, Free PMC Article
  4. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Tumbale P, et al. Nature, 2014 Feb 6. PMID 24362567, Free PMC Article
  5. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA 5'-adenosine monophosphate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA 5'-adenosine monophosphate hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-3'-diphospho-5'-guanosine diphosphatase IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanosine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mismatched DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-strand break-containing DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-strand break-containing DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in single strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aprataxin-like protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1970754..1973820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023379.3 → NP_588388.1  aprataxin-like protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588388.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74859
    Conserved Domains (2) summary
    pfam01230
    Location:45 → 156
    HIT; HIT domain
    pfam16278
    Location:172 → 224
    zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
Nucleotide Protein
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