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gad8 serine/threonine protein kinase (AGC family) Gad8 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539206, updated on 18-Sep-2024

Summary

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Official Symbol
gad8
Official Full Name
serine/threonine protein kinase (AGC family) Gad8
Primary source
PomBase:SPCC24B10.07
Locus tag
SPOM_SPCC24B10.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See gad8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (912500..915238)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Tim9-Tim10 complex subunit Tim9 Neighboring gene ncRNA Neighboring gene SAGA complex subunit Ada2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast. Pataki E, et al. PLoS Genet, 2020 Nov. PMID 33137119, Free PMC Article
  2. TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium. Baker K, et al. Elife, 2019 Sep 30. PMID 31566560, Free PMC Article
  3. Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe. Ahamad N, et al. Eur J Cell Biol, 2018 May. PMID 29699848
  4. Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2. Du W, et al. Open Biol, 2016 Mar. PMID 26935949, Free PMC Article
  5. Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition. Hálová L, et al. J Cell Biol, 2013 Nov 25. PMID 24247430, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
    Title: TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
  2. Here, the authors define a novel regulatory mechanism by which the motor activity and function of the fission yeast type one myosin, Myo1, is modulated by TORC2-signalling-dependent phosphorylation via Gad8.
    Title: TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium.
  3. The Gad8 kinase (AKT homologue) phosphorylates fission yeast Tor1 at threonine (T1972) to reduce activity.
    Title: Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
  4. Increased PKC(Pck2) expression prevented Gad8-TORC2 binding and so reduced the TORC2-mediated phosphorylation of Gad8 serine 546 that activates Gad8.
    Title: Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2.
  5. findings highlight the significance of glucose availability in regulation of TORC2-Gad8 and indicate a novel link between the cAMP/PKA, Pmk1/MAPK, and TORC2-Gad8 signaling
    Title: Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
  6. Gad8 positively regulates expression of cyclin-dependent kinase inhibitor gene rum1+, which is essential for cell cycle arrest.
    Title: Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISM
Inferred from Sequence Model
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of induction of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine protein kinase (AGC family) Gad8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    912500..915238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023001.3 → NP_588010.1  serine/threonine protein kinase (AGC family) Gad8 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P7J8
    Conserved Domains (3) summary
    PTZ00263
    Location:214 → 545
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd11651
    Location:66 → 225
    YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1
    cd05585
    Location:235 → 547
    STKc_YPK1_like; Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases
Nucleotide Protein
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