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ubp5 ubiquitin hydrolase Ubp5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539385, updated on 18-Sep-2024

Summary

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Official Symbol
ubp5
Official Full Name
ubiquitin hydrolase Ubp5
Primary source
PomBase:SPCC188.08c
Locus tag
SPOM_SPCC188.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ubp5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003421.2 (1488553..1492479, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene shelterin complex HEAT repeat subunit Ccq1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene flocculin Pfl4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p. Richert K, et al. Mol Genet Genomics, 2002 Mar. PMID 11919719
  2. A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival. Beckley JR, et al. Mol Cell Proteomics, 2015 Dec. PMID 26412298, Free PMC Article
  3. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. Kouranti I, et al. PLoS Biol, 2010 Sep 7. PMID 20838651, Free PMC Article
  4. Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing. Thakran P, et al. EMBO J, 2018 Jan 4. PMID 28947618, Free PMC Article
  5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal-dependent deubiquitinase activity HDA PubMed 
enables metal-dependent deubiquitinase activity HMP PubMed 
enables metal-dependent deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin hydrolase Ubp5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1488553..1492479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023201.3 → NP_588211.1  ubiquitin hydrolase Ubp5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588211.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09879, Q10433, Q9Y7P5
    Conserved Domains (5) summary
    COG5077
    Location:15 → 1107
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:211 → 530
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03775
    Location:56 → 188
    MATH_Ubp21p; Ubiquitin-specific protease 21 (Ubp21p) family, MATH domain; composed of fungal proteins with similarity to Ubp21p of fission yeast. Ubp21p is a deubiquitinating enzyme that may be involved in the regulation of the protein kinase Prp4p, which controls ...
    pfam12436
    Location:631 → 881
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:892 → 1092
    USP7_C2; Ubiquitin-specific protease C-terminal
Nucleotide Protein
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