U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

isa1 Fe-sulfur protein Isa1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539409, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
isa1
Official Full Name
Fe-sulfur protein Isa1
Primary source
PomBase:SPCC645.03c
Locus tag
SPOM_SPCC645.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See isa1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1230674..1231856, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G1/S-specific B-type cyclin Cig1 Neighboring gene cardiolipin synthase PGP phosphatase domain-containing Gep4 Neighboring gene ncRNA Neighboring gene Smc5-6 complex non-SMC MAGE family subunit Nse3 Neighboring gene myosin II heavy chain myo2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking. Fidai I, et al. J Biol Inorg Chem, 2016 Oct. PMID 27590019
  2. Iron-sulfur cluster biosynthesis. A comparative kinetic analysis of native and Cys-substituted ISA-mediated [2Fe-2S]2+ cluster transfer to an apoferredoxin target. Wu SP, et al. Biochemistry, 2003 May 20. PMID 12741836
  3. Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. Brancaccio D, et al. J Am Chem Soc, 2014 Nov 19. PMID 25347204
  4. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20085751
  5. Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism. Shi R, et al. Front Cell Dev Biol, 2021. PMID 34660592, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that Grx5 plays a central role in Fe-S assembly process through interaction with A-type Fe-S scaffold proteins Isa1 and Isa2.
    Title: Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in [4Fe-4S] cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial [4Fe-4S] assembly complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Fe-sulfur protein Isa1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1230674..1231856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023102.3 → NP_588112.1  Fe-sulfur protein Isa1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588112.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78859
    Conserved Domains (1) summary
    TIGR00049
    Location:84 → 188
    TIGR00049; Iron-sulfur cluster assembly accessory protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous