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nse3 Smc5-6 complex non-SMC MAGE family subunit Nse3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539436, updated on 18-Sep-2024

Summary

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Official Symbol
nse3
Official Full Name
Smc5-6 complex non-SMC MAGE family subunit Nse3
Primary source
PomBase:SPCC645.04
Locus tag
SPOM_SPCC645.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See nse3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1232078..1233374)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene cardiolipin synthase PGP phosphatase domain-containing Gep4 Neighboring gene ncRNA Neighboring gene Fe-sulfur protein Isa1 Neighboring gene myosin II heavy chain myo2 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Andrews EA, et al. Mol Cell Biol, 2005 Jan. PMID 15601841, Free PMC Article
  2. The SAGA histone acetyltransferase module targets SMC5/6 to specific genes. Mahrik L, et al. Epigenetics Chromatin, 2023 Feb 16. PMID 36793083, Free PMC Article
  3. A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6. Vondrova L, et al. Sci Rep, 2020 Jun 16. PMID 32546830, Free PMC Article
  4. Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Zabrady K, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26446992, Free PMC Article
  5. The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits. Palecek J, et al. J Biol Chem, 2006 Dec 1. PMID 17005570

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
    Title: A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
  2. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that several MAGE proteins can interact with at least one of the NSE4/EID proteins.
    Title: Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.
  3. Nse3 is a non-SMC subunit of the Smc5+6 complex. It is an essential nuclear protein that is important for normal mitotic chromosome segregation, meiosis, DNA repair via homologous recombination, and replication fork stability. [Nse3]
    Title: Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Smc5-6 complex non-SMC MAGE family subunit Nse3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1232078..1233374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023103.3 → NP_588113.1  Smc5-6 complex non-SMC MAGE family subunit Nse3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588113.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y7U4
    Conserved Domains (1) summary
    pfam01454
    Location:97 → 291
    MAGE; MAGE family
Nucleotide Protein
Heading Accession and Version

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