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ksg1 serine/threonine protein kinase Ksg1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539517, updated on 18-Sep-2024

Summary

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Official Symbol
ksg1
Official Full Name
serine/threonine protein kinase Ksg1
Primary source
PomBase:SPCC576.15c
Locus tag
SPOM_SPCC576.15C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ksg1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (2103938..2106290, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene FANCM-MHF complex subunit Mhf2 Neighboring gene Swr1 complex subunit Swc5 Neighboring gene ncRNA Neighboring gene diphthine synthase Dph5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1. Tang Y, et al. Genetics, 2004 Dec. PMID 15611161, Free PMC Article
  2. A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation. Niederberger C, et al. Mol Gen Genet, 1999 Feb. PMID 10071224
  3. Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe. Gräub R, et al. J Basic Microbiol, 2003. PMID 14625898
  4. Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. Matsuo T, et al. EMBO J, 2003 Jun 16. PMID 12805221, Free PMC Article
  5. Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast. Madrid M, et al. J Biol Chem, 2017 Jul 7. PMID 28536259, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that in vivo phosphorylation of Pck2 at the conserved T842 activation loop during growth and in response to different stresses is mediated by the phosphoinositide-dependent kinase (PDK) ortholog Ksg1 and an autophosphorylation mechanism
    Title: Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.
  2. Protein kinase A is a physiological substrate
    Title: In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fungal-type cell wall organization or biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase Ksg1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2103938..2106290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023433.3 → NP_588442.1  serine/threonine protein kinase Ksg1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588442.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q12701
    Conserved Domains (2) summary
    smart00220
    Location:99 → 366
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05581
    Location:97 → 366
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
Nucleotide Protein
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