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pof3 F-box protein Pof3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539527, updated on 18-Sep-2024

Summary

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Official Symbol
pof3
Official Full Name
F-box protein Pof3
Primary source
PomBase:SPCC338.16
Locus tag
SPOM_SPCC338.16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pof3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1345278..1347275, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic cohesin complex non-SMC subunit Rad21 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit Wbp1 Neighboring gene ncRNA Neighboring gene adenosine kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation. Mamnun YM, et al. Biochem Biophys Res Commun, 2006 Nov 10. PMID 16997270
  2. F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast. Qiu C, et al. J Cell Sci, 2018 Feb 2. PMID 29361524
  3. Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex. Roseaulin LC, et al. PLoS Genet, 2013. PMID 23349636, Free PMC Article
  4. Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe. Sugioka-Sugiyama R, et al. Biochem Biophys Res Commun, 2011 Mar 18. PMID 21333630
  5. Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function. Takayama Y, et al. Dev Cell, 2010 Mar 16. PMID 20230746, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. propose that Hsk1 plays a vital role during post S phase in genome stability via SCF(Pof3)-mediated degradation of Ams2, thereby maintaining centromere integrity
    Title: Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.
  2. isolate Mcl1 as an interaction partner of the F-box protein Pof3, which is a component of the ubiquitin ligase complex SCF(Pof3)
    Title: Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in donor selection IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitotic cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
F-box protein Pof3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1345278..1347275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023141.3 → NP_588152.1  F-box protein Pof3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588152.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74991
    Conserved Domains (4) summary
    sd00034
    Location:454 → 478
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00006
    Location:40 → 70
    TPR; TPR repeat [structural motif]
    pfam12937
    Location:136 → 173
    F-box-like; F-box-like
    pfam13414
    Location:7 → 71
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version

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