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tpx1 thioredoxin peroxidase Tpx1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539572, updated on 18-Sep-2024

Summary

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Official Symbol
tpx1
Official Full Name
thioredoxin peroxidase Tpx1
Primary source
PomBase:SPCC576.03c
Locus tag
SPOM_SPCC576.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See tpx1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (2084942..2085719, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hydantoin racemase family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BAX inhibitor family protein Bxi1 Neighboring gene ncRNA Neighboring gene nuclear export factor sac3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C-terminal truncation of the peroxiredoxin Tpx1 decreases its sensitivity for hydrogen peroxide without compromising its role in signal transduction. Jara M, et al. Genes Cells, 2008 Feb. PMID 18233959
  2. A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms. Cao M, et al. Mol Cell, 2023 Sep 7. PMID 37572670
  3. Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe. Normant V, et al. Mol Microbiol, 2021 Apr. PMID 33140466
  4. Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe. Kang GY, et al. Mol Biol Rep, 2008 Sep. PMID 17530441
  5. A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Veal EA, et al. Mol Cell, 2004 Jul 2. PMID 15225554

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe.
    Title: Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe.
  2. Tpx1 is the only enzyme with sufficient sensitivity for peroxides and cellular abundance as to control the low levels produced during aerobic growth, catalase being the next barrier of detoxification.
    Title: A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.
  3. our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe
    Title: Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
  4. Thioredoxin Peroxidase inhibited thermal aggregation of citrate synthase, but BCP failed to inhibit the aggregation.
    Title: Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe.
  5. Prx protein is partly responsible for maintaining low ROS level under normal and stressful growth conditions in the fission yeast
    Title: Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe.
  6. the carboxy-terminal extension of Tpx1 concomitantly improves H2O2 scavenging and increases susceptibility to inactivation
    Title: C-terminal truncation of the peroxiredoxin Tpx1 decreases its sensitivity for hydrogen peroxide without compromising its role in signal transduction.
  7. redox regulation of the thioredoxin peroxidase activity of Tpx1 acts as a molecular switch controlling the transcriptional response to H(2)O(2)
    Title: Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide.
  8. The peroxiredoxin Tpx1 is an upstream activator of Pap1. Tpx1 oxidation to the cysteine-sulfinic acid constitutes a previously uncharacterized redox switch in H2O2 signaling, restricting Pap1 activation within a narrow range of H2O2 concentrations. [Tpx1]
    Title: A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables MAP-kinase scaffold activity EXP
Inferred from Experiment
more info
 PubMed 
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase activity EXP
Inferred from Experiment
more info
 PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin peroxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thioredoxin-dependent peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular detoxification of hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
thioredoxin peroxidase Tpx1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2084942..2085719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023421.3 → NP_588430.1  thioredoxin peroxidase Tpx1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588430.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74887
    Conserved Domains (2) summary
    COG0450
    Location:1 → 192
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:5 → 176
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Nucleotide Protein
Heading Accession and Version

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