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cnp3 centromere protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539620, updated on 18-Sep-2024

Summary

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Official Symbol
cnp3
Official Full Name
centromere protein
Primary source
PomBase:SPBC1861.01c
Locus tag
SPOM_SPBC1861.01C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mif2; SPBC56F2.13
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Genomic context

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See cnp3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (4126318..4128666, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box protein Pof12 Neighboring gene mitochondrial 54S ribosomal protein mL53 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of Dam tagging and chromatin immunoprecipitation as tools for the identification of the binding sites for S. pombe CENP-C. Holland S, et al. Chromosome Res, 2005. PMID 15791413
  2. Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation. Suma M, et al. G3 (Bethesda), 2018 Jul 31. PMID 29925533, Free PMC Article
  3. Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. Chik JK, et al. J Biol Chem, 2019 Sep 20. PMID 31366733, Free PMC Article
  4. The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I. Yokobayashi S, et al. Cell, 2005 Dec 2. PMID 16325576
  5. Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis. Zhou X, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180432, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cnp3-1 mutant is prone to promiscuous accumulation of Cnp1 at non-centromeric regions. Cnp3 plays a role in restricting the site of accumulation of Cnp1 and thus prevents formation of de novo centromeres.
    Title: Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation.
  2. Residues 26-50 in Cnp3 are responsible for interacting with the Mis12 complex. Cnp3 is a substrate of Ark1 and phosphorylation impairs the interaction between the Cnp3 and Mis12 complex.
    Title: Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis.
  3. CENP-C serves as a scaffold for the specific recruitment of essential kinetochore proteins
    Title: CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables centromeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables centromeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinetochore adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables kinetochore adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle attachment to meiosis I kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle attachment to meiosis I kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
centromere protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4126318..4128666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355836.2 → NP_001342907.1  centromere protein [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9USR9, Q9USY5
    Conserved Domains (2) summary
    pfam15624
    Location:18 → 69
    Mif2_N; Kinetochore CENP-C fungal homolog, Mif2, N-terminal
    cl21464
    Location:539 → 624
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials