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cut2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539641, updated on 11-Sep-2024

Summary

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Official Symbol
cut2
Primary source
PomBase:SPBC14C8.01c
Locus tag
SPOM_SPBC14C8.01C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPBC1815.02c
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2203000..2204216, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene enolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TIM23 translocase complex subunit Tim44

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase. Vijayakumari D, et al. Cell Rep, 2022 Mar 22. PMID 35320724, Free PMC Article
  2. Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase. Nagao K, et al. Genes Cells, 2006 Mar. PMID 16483313
  3. Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin. Yanagida M. Genes Cells, 2000 Jan. PMID 10651900
  4. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis. Kumada K, et al. Curr Biol, 1998 May 21. PMID 9635190
  5. Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Funabiki H, et al. Nature, 1996 May 30. PMID 8632802

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of separase-securin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
securin cut2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2203000..2204216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021811.4 → NP_595904.3  securin cut2 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P21135, Q9UUM0
Nucleotide Protein
Heading Accession and Version

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Research Materials