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pck2 protein kinase C (PKC)-like Pck2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539649, updated on 18-Sep-2024

Summary

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Official Symbol
pck2
Official Full Name
protein kinase C (PKC)-like Pck2
Primary source
PomBase:SPBC12D12.04c
Locus tag
SPOM_SPBC12D12.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mok3; pkc1; sts6
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Genomic context

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See pck2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2309126..2313008, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chaperonin-containing T-complex alpha subunit Cct1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene calcium-binding subfamily carrier protein Neighboring gene DNA polymerase zeta Rev7 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control. Kobori H, et al. J Cell Sci, 1994 May. PMID 7929623
  2. Rkp1/Cpc2, a fission yeast RACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling. Won M, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263963
  3. Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. Toda T, et al. EMBO J, 1993 May. PMID 8491190, Free PMC Article
  4. Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe. Gräub R, et al. J Basic Microbiol, 2003. PMID 14625898
  5. Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake. Carnero E, et al. Mol Gen Genet, 2000 Sep. PMID 11016847

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Constitutive Pck activation promoted dephosphorylation and destabilization of Pck2, whereas it enhanced Pck1 levels to interfere with proper downstream signaling to the cell integrity pathway via Pck2.
    Title: Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast.
  2. We show that in vivo phosphorylation of Pck2 at the conserved T842 activation loop during growth and in response to different stresses is mediated by the phosphoinositide-dependent kinase (PDK) ortholog Ksg1 and an autophosphorylation mechanism
    Title: Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.
  3. both Rho1 and Pck1 are positive upstream regulatory members of the CIP in addition to Rho2 and Pck2.
    Title: Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables lipid binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell integrity MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment or maintenance of cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C (PKC)-like Pck2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2309126..2313008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021859.3 → NP_595950.1  protein kinase C (PKC)-like Pck2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595950.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36583, Q9UU42
    Conserved Domains (6) summary
    cd08689
    Location:213 → 320
    C2_fungal_Pkc1p; C2 domain found in protein kinase C (Pkc1p) in Saccharomyces cerevisiae
    cd11620
    Location:115 → 186
    HR1_PKC-like_2_fungi; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins
    cd11621
    Location:2 → 73
    HR1_PKC-like_1_fungi; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins
    smart00220
    Location:683 → 942
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05570
    Location:688 → 1003
    STKc_PKC; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C
    pfam00130
    Location:406 → 454
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version

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