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pht1 histone H2A.Z-like protein Pht1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539668, updated on 18-Sep-2024

Summary

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Official Symbol
pht1
Official Full Name
histone H2A.Z-like protein Pht1
Primary source
PomBase:SPBC11B10.10c
Locus tag
SPOM_SPBC11B10.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pht1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (1502203..1503444, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene protein wwm1 Neighboring gene ncRNA Neighboring gene cyclin-dependent protein kinase Cdk1/Cdc2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maintenance of meiotic crossover against reduced double-strand break formation in fission yeast lacking histone H2A.Z. Yamada T, et al. Gene, 2020 Jun 15. PMID 32222534
  2. Improved tools for efficient mapping of fission yeast genes: identification of microtubule nucleation modifier mod22-1 as an allele of chromatin- remodelling factor gene swr1. Anders A, et al. Yeast, 2008 Dec. PMID 19160458, Free PMC Article
  3. Podbat: a novel genomic tool reveals Swr1-independent H2A.Z incorporation at gene coding sequences through epigenetic meta-analysis. Sadeghi L, et al. PLoS Comput Biol, 2011 Aug. PMID 21901086, Free PMC Article
  4. Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe. Ahmed S, et al. Genetics, 2007 Nov. PMID 17947424, Free PMC Article
  5. Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading. Dong Q, et al. Mol Cell, 2016 Oct 6. PMID 27666591, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic as well as genome-wide analyses implied a possibility that, even without H2A.Z, meiotic crossovers (COs) in Schizosaccharomyces pombe are maintained by weak and non-hotspot double-strand breaks, which are processed preferentially as CO. These observations provide clues to further understanding on CO control.
    Title: Maintenance of meiotic crossover against reduced double-strand break formation in fission yeast lacking histone H2A.Z.
  2. Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to suppress expression of antisense and repeat element transcripts throughout the fission yeast genome.
    Title: Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
  3. Deletion or an unacetylatable mutation of Pht1 leads to genome instability, primarily caused by chromosome entanglement and breakage at anaphase.
    Title: An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.
  4. Mod22-1, a modifier of microtubule nucleation phenotypes, encodes a truncation allele of Swr1, a chromatin-remodelling factor involved in nucleosomal deposition of H2A.Z histone variant Pht1.
    Title: Improved tools for efficient mapping of fission yeast genes: identification of microtubule nucleation modifier mod22-1 as an allele of chromatin- remodelling factor gene swr1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding ISM
Inferred from Sequence Model
more info
  
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CENP-A eviction from euchromatin IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin EXP
Inferred from Experiment
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone H2A.Z-like protein Pht1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1502203..1503444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021524.4 → NP_595630.3  histone H2A.Z-like protein Pht1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595630.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P48003
    Conserved Domains (2) summary
    COG5262
    Location:18 → 139
    HTA1; Histone H2A [Chromatin structure and dynamics]
    cd00074
    Location:25 → 127
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
Nucleotide Protein
Heading Accession and Version

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