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alp1 tubulin-specific chaperone cofactor D Alp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539669, updated on 18-Sep-2024

Summary

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Official Symbol
alp1
Official Full Name
tubulin-specific chaperone cofactor D Alp1
Primary source
PomBase:SPBC11C11.04c
Locus tag
SPOM_SPBC11C11.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
tsm1
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Genomic context

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See alp1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003423.3 (3353046..3357047, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene protein Ndc80 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene KRE9-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tubulin heterodimers remain functional for one cell cycle after the inactivation of tubulin-folding cofactor D in fission yeast cells. Fedyanina OS, et al. Yeast, 2009 Apr. PMID 19330768, Free PMC Article
  2. Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast. Hirata D, et al. EMBO J, 1998 Feb 2. PMID 9450991, Free PMC Article
  3. The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2. Mori R, et al. Mol Biol Cell, 2013 Jun. PMID 23576550, Free PMC Article
  4. Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D. Fedyanina OS, et al. Curr Genet, 2006 Nov. PMID 17004072
  5. A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast. Radcliffe PA, et al. FEBS Lett, 2000 Feb 18. PMID 10683446

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When cofactor D function is perturbed in cells blocked in G(2), cytoplasmic microtubules appear normal for 2-3 h but thereafter they disintegrate quickly, so that only a few short MTs remain.
    Title: Tubulin heterodimers remain functional for one cell cycle after the inactivation of tubulin-folding cofactor D in fission yeast cells.
  2. Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor
    Title: Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle HDA PubMed 
is_active_in nucleus HDA PubMed 
part_of tubulin folding cofactor complex NAS
Non-traceable Author Statement
more info
  

General protein information

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Preferred Names
tubulin-specific chaperone cofactor D Alp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3353046..3357047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022314.3 → NP_596393.2  tubulin-specific chaperone cofactor D Alp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596393.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78749, Q10197
    Conserved Domains (1) summary
    COG5234
    Location:13 → 1105
    CIN1; Beta-tubulin folding cofactor D [Posttranslational modification, protein turnover, chaperones / Cytoskeleton]
Nucleotide Protein
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