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frp1 Fe(3+)-chelate reductase Frp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539711, updated on 22-Jun-2024

Summary

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Gene symbol
frp1
Gene description
Fe(3+)-chelate reductase Frp1
Locus tag
SPOM_SPBC1683.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag
SPBC1683.09c
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Genomic context

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See frp1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (160357..162392, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hexose transporter Ght4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fe(2+) transporter Pcl1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase. Roman DG, et al. Mol Cell Biol, 1993 Jul. PMID 8321236, Free PMC Article
  2. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
  3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
  4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
  5. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ferric-chelate reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ferric-chelate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding ISM
Inferred from Sequence Model
more info
  
enables iron ion binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in cellular response to iron ion starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in copper ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in reductive iron assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reductive iron assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fe(3+)-chelate reductase Frp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    160357..162392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020971.3 → NP_595065.1  Fe(3+)-chelate reductase Frp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595065.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q04800
    Conserved Domains (3) summary
    cd06186
    Location:279 → 480
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:124 → 235
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam08030
    Location:414 → 547
    NAD_binding_6; Ferric reductase NAD binding domain
Nucleotide Protein
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