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leo1 RNA polymerase II-associated Paf1 complex protein Leo1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539726, updated on 17-Aug-2024

Summary

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Gene symbol
leo1
Gene description
RNA polymerase II-associated Paf1 complex protein Leo1
Primary source
PomBase:SPBC13E7.08c
Locus tag
SPOM_SPBC13E7.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See leo1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (3052520..3055140, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pig-M family mannosyltransferase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene microtubule-anchoring factor Msd1 Neighboring gene verprolin Neighboring gene transcription factor TFIIIB subunit Brf1 Neighboring gene rhomboid protease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence. Oya E, et al. Epigenetics Chromatin, 2019 Jul 17. PMID 31315658, Free PMC Article
  2. The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Seo HD, et al. Curr Genet, 2018 Jun. PMID 29214404
  3. Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms. Chen JJ, et al. Mol Cell Biol, 2020 Jul 14. PMID 32366382, Free PMC Article
  4. The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast. Sadeghi L, et al. EMBO Rep, 2015 Dec. PMID 26518661, Free PMC Article
  5. TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes. Cohen A, et al. PLoS Genet, 2022 Feb. PMID 35157728, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II C-terminal domain phosphoserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin boundary formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA polymerase II-associated Paf1 complex protein Leo1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3052520..3055140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022183.3 → NP_596263.1  RNA polymerase II-associated Paf1 complex protein Leo1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596263.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P6R2
    Conserved Domains (1) summary
    pfam04004
    Location:89 → 248
    Leo1; Leo1-like protein
Nucleotide Protein
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