U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pab2 poly(A)-binding protein Pab2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539733, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
pab2
Official Full Name
poly(A)-binding protein Pab2
Primary source
PomBase:SPBC16E9.12c
Locus tag
SPOM_SPBC16E9.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPBC16E6.12c
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pab2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (1939371..1940788, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene HECT-type ubiquitin-protein ligase Pub3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ksp1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast. Mallet PL, et al. Genetics, 2017 Feb. PMID 28007890, Free PMC Article
  2. A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1. Mallet PL, et al. Traffic, 2013 Mar. PMID 23279110
  3. The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation. Kühn U, et al. RNA, 2017 Apr. PMID 28096519, Free PMC Article
  4. The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs. Lemay JF, et al. Mol Cell, 2010 Jan 15. PMID 20129053
  5. A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein. Lemieux C, et al. Mol Cell, 2011 Oct 7. PMID 21981922

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whereas PABPN1 strongly increases the activity of its cognate poly(A) polymerase in vitro, Pab2 was unable to stimulate Pla1 to any significant extent.
    Title: The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.
  2. Pab2 functions with Rrp6 to negatively control Tf2 mRNA accumulation. the absence of Pab2 attenuated the derepression of Tf2 transcription and the increased frequency of Tf2 mobilization caused by the deletion of abp1.
    Title: Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast.
  3. Nab2 impedes Pab2/Rrp6-mediated decay by competing with Pab2 for polyadenylated transcripts in the nucleus.
    Title: Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.
  4. A proline-tyrosine nuclear localization signal is necessary and sufficient for nuclear import of Pab2.
    Title: A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1.
  5. Pab2 and the nuclear exosome subunit, Rrp6 are the main factors involved in this polyadenylation-dependent pre-mRNA degradation pathway
    Title: A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.
  6. a model in which Mmi1 selectively targets meiotic transcripts for degradation via Pab2 and the exosome
    Title: Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.
  7. Pab2 promotes poly(A) tail trimming from pre-snoRNAs by recruiting the nuclear exosome.
    Title: The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-RNA adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Mei2 nuclear dot complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cleavage body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear exosome focus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolar peripheral inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
poly(A)-binding protein Pab2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1939371..1940788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021695.3 → NP_595794.1  poly(A)-binding protein Pab2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595794.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14327
    Conserved Domains (3) summary
    COG0724
    Location:1 → 138
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12306
    Location:56 → 128
    RRM_II_PABPs; RNA recognition motif in type II polyadenylate-binding proteins
    cl21462
    Location:8 → 47
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials