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lys4 homocitrate synthase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539815, updated on 18-Sep-2024

Summary

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Official Symbol
lys4
Official Full Name
homocitrate synthase
Primary source
PomBase:SPBC1105.02c
Locus tag
SPOM_SPBC1105.02C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See lys4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3505708..3507548, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PSP1 family protein Neighboring gene ncRNA Neighboring gene rRNA-processing Rrp12-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial 54S ribosomal protein uL16m Neighboring gene protein tam12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. Bulfer SL, et al. J Biol Chem, 2009 Dec 18. PMID 19776021, Free PMC Article
  2. Structural basis for L-lysine feedback inhibition of homocitrate synthase. Bulfer SL, et al. J Biol Chem, 2010 Apr 2. PMID 20089861, Free PMC Article
  3. Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe. Kwon ES, et al. J Biol Chem, 2006 Jan 20. PMID 16299000
  4. Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe. Ye ZH, et al. J Bacteriol, 1988 Dec. PMID 3142867, Free PMC Article
  5. Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast. Ma Y, et al. Curr Genet, 2007 Aug. PMID 17622533

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
    Title: Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
  2. A putative homocitrate synthase, encoded by the lys4 gene, is a labile target of oxidative stress caused by copper/zinc-containing superoxide dismutase depletion. Its synthesis is positively regulated by Phx1, a putative transcriptional regulator.
    Title: Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables homocitrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables homocitrate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables homocitrate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lysine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process via aminoadipic acid EXP
Inferred from Experiment
more info
 PubMed 
involved_in lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in mitochondrial matrix IC
Inferred by Curator
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homocitrate synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3505708..3507548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022377.3 → NP_596458.1  homocitrate synthase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596458.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y823
    Conserved Domains (1) summary
    cd07948
    Location:35 → 296
    DRE_TIM_HCS; Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain
Nucleotide Protein
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