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pmk1 MAP kinase Pmk1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539920, updated on 18-Sep-2024

Summary

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Official Symbol
pmk1
Official Full Name
MAP kinase Pmk1
Primary source
PomBase:SPBC119.08
Locus tag
SPOM_SPBC119.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
spm1
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Genomic context

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See pmk1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (730816..732952)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene copper chaperone Sco1 Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Vps15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ORMDL family protein Neighboring gene asparagine synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biological significance of nuclear localization of mitogen-activated protein kinase Pmk1 in fission yeast. Sánchez-Mir L, et al. J Biol Chem, 2012 Jul 27. PMID 22685296, Free PMC Article
  2. Stress-activated protein kinase-mediated down-regulation of the cell integrity pathway mitogen-activated protein kinase Pmk1p by protein phosphatases. Madrid M, et al. Mol Biol Cell, 2007 Nov. PMID 17761528, Free PMC Article
  3. Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe. Zaitsevskaya-Carter T, et al. EMBO J, 1997 Mar 17. PMID 9135147, Free PMC Article
  4. A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe. Zhou X, et al. PLoS One, 2013. PMID 23738021, Free PMC Article
  5. Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity. Cansado J, et al. Commun Integr Biol, 2010 Sep. PMID 21057634, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. propose that the gas1-287 mutation causes longevity as the similar mechanism as cell wall stress depending on Pmk1 and Sty1 MAPK pathways
    Title: gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe.
  2. Threonine-monophosphorylated Pmk1 was able to execute most of the biological functions of the dually phosphorylated kinase.
    Title: Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.
  3. T842 phosphorylation is not essential for Pmk1 activation, and putative phosphorylation at T846 might play an additional role in Pck2 catalytic activation and downstream signaling
    Title: Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.
  4. Consistently, the phosphorylation of Pmk1 MAPK on heat shock was decreased in the cwg2-v2 mutants, and rho4- and rho5-null cells.
    Title: Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.
  5. findings highlight the significance of glucose availability in regulation of TORC2-Gad8 and indicate a novel link between the cAMP/PKA, Pmk1/MAPK, and TORC2-Gad8 signaling
    Title: Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
  6. Data indicate that mutation of any of the two first amino acids in the IYT motif led to a failure of inactive dual-specificity MAPK phosphatases Sdp1 to trap mitogen-activated protein kinase Slt2.
    Title: A conserved non-canonical docking mechanism regulates the binding of dual specificity phosphatases to cell integrity mitogen-activated protein kinases (MAPKs) in budding and fission yeasts.
  7. down-regulation of nuclear Pmk1 by MAPK phosphatases induced by the stress activated protein kinase pathway is important for the fine modulation of extranuclear Pmk1 activity.
    Title: Biological significance of nuclear localization of mitogen-activated protein kinase Pmk1 in fission yeast.
  8. Results suggest that Activation of Atf1 is not fully dependent on Sty1 and Pmk1.
    Title: A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.
  9. Results suggest that Ecm33 gene expression is regulated by Atf1 and Mbx1, and taht Ecm33 is involved in the negative feedback regulation of Pmk1 cell integrity signaling and is linked to cellular Ca(2+) signaling.
    Title: The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast.
  10. Pmk1 mitogen-activated protein kinase (MAPK) directly phosphorylates Nrd1, thereby negatively regulating the binding activity of Nrd1 to Cdc4 mRNA.
    Title: Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell integrity MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell integrity MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell wall organization or biogenesis EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of cell wall organization or biogenesis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP kinase Pmk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    730816..732952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021196.3 → NP_595289.1  MAP kinase Pmk1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595289.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q92398
    Conserved Domains (2) summary
    cd07857
    Location:20 → 351
    STKc_MPK1; Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1
    smart00220
    Location:21 → 314
    S_TKc; Serine/Threonine protein kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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