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uba2 SUMO E1-like activator enzyme Uba2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539967, updated on 18-Sep-2024

Summary

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Official Symbol
uba2
Official Full Name
SUMO E1-like activator enzyme Uba2
Primary source
PomBase:SPBC16H5.03c
Locus tag
SPOM_SPBC16H5.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
fub2
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Genomic context

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See uba2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (2294934..2297241)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pho88 family protein Neighboring gene ncRNA Neighboring gene 6-phosphofructokinase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular mimicry of SUMO promotes DNA repair. Prudden J, et al. Nat Struct Mol Biol, 2009 May. PMID 19363481, Free PMC Article
  2. Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Andrews EA, et al. Mol Cell Biol, 2005 Jan. PMID 15601841, Free PMC Article
  3. SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52. Ho JC, et al. Nucleic Acids Res, 2001 Oct 15. PMID 11600706, Free PMC Article
  4. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Wei Y, et al. Mol Cell, 2017 Jun 1. PMID 28552615
  5. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables SUMO activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO conjugating enzyme activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein sumoylation EXP
Inferred from Experiment
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
SUMO E1-like activator enzyme Uba2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2294934..2297241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021853.3 → NP_595945.1  SUMO E1-like activator enzyme Uba2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595945.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42939
    Conserved Domains (3) summary
    COG0476
    Location:1 → 288
    ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
    cd01489
    Location:27 → 433
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam14732
    Location:442 → 503
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
Nucleotide Protein
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