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cdc18 MCM loader [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540013, updated on 18-Sep-2024

Summary

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Official Symbol
cdc18
Official Full Name
MCM loader
Primary source
PomBase:SPBC14C8.07c
Locus tag
SPOM_SPBC14C8.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cdc18 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2215955..2217984, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARP2/3 actin-organizing complex WD repeat subunit Sop2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein tam10 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Nishitani H, et al. Cell, 1995 Nov 3. PMID 8521469
  2. The regulation of competence to replicate in meiosis by Cdc6 is conserved during evolution. Lemaître JM, et al. Mol Reprod Dev, 2004 Sep. PMID 15278909
  3. Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe. Guan L, et al. J Biol Chem, 2017 Apr 14. PMID 28223353, Free PMC Article
  4. The fission yeast cdc18+ gene product couples S phase to START and mitosis. Kelly TJ, et al. Cell, 1993 Jul 30. PMID 7916658
  5. Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. Kearsey SE, et al. EMBO J, 2000 Apr 3. PMID 10747035, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cdc18 as a binding partner of Swi6 has no silencing defect at the centromere, but changes Swi6 distribution and accelerates the timing of centromere replication.
    Title: S. pombe replication protein Cdc18 (Cdc6) interacts with Swi6 (HP1) heterochromatin protein: region specific effects and replication timing in the centromere.
  2. An elevated level of Cdc18 activates the Rad3-dependent checkpoint either directly or indirectly, and additionally causes expansion of the rDNA repeats on Chromosome III.
    Title: Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.
  3. demonstrated that within the promoter of cdc18+, a representative pre-S gene, the orientation and spacing of MCBs are crucial for activation and cell-cycle dependence
    Title: Transcription of the Schizosaccharomyces pombe gene cdc18+: roles of MCB elements and the DSC1 complex.
  4. S phase arrest activates the S phase checkpoint blocking mitosis onset and inhibiting Cdc18 degradation.
    Title: Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MCM complex loading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic pre-replicative complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pre-replicative complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear replication fork IC
Inferred by Curator
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MCM loader

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2215955..2217984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021818.3 → NP_595910.1  MCM loader [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595910.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P41411
    Conserved Domains (3) summary
    cd00009
    Location:170 → 333
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cd08768
    Location:478 → 560
    Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
    COG1474
    Location:169 → 571
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
Nucleotide Protein
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