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pcn1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540020, updated on 22-Aug-2024

Summary

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Official Symbol
pcn1
Primary source
PomBase:SPBC16D10.09
Locus tag
SPOM_SPBC16D10.09
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
pcn
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Genomic context

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Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (3616595..3617845)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene heat shock protein Hsp104 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA specific adenosine-34 deaminase subunit Tad2 Neighboring gene 40S ribosomal protein uS13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast. Meister P, et al. EMBO J, 2007 Mar 7. PMID 17304223, Free PMC Article
  2. Schizosaccharomyces pombe proliferating cell nuclear antigen mutations affect DNA polymerase delta processivity. Arroyo MP, et al. J Biol Chem, 1996 Jul 5. PMID 8663159
  3. Histone chaperone networks shaping chromatin function. Hammond CM, et al. Nat Rev Mol Cell Biol, 2017 Mar. PMID 28053344, Free PMC Article
  4. Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation. Guarino E, et al. Nucleic Acids Res, 2011 Aug. PMID 21493688, Free PMC Article
  5. Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe. Ramasubramanyan S, et al. DNA Repair (Amst), 2010 Jul 1. PMID 20452294

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCNA is ubiquitinated in response to DNA damage when cells are arrested in G2.(PCNA)
    Title: Postreplication repair and PCNA modification in Schizosaccharomyces pombe.
  2. These data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication.
    Title: Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IC
Inferred by Curator
more info
 PubMed 
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA polymerase processivity factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA strand elongation involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UV-damage excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in error-free translesion synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in error-prone translesion synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication lagging strand elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication leading strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in postreplication repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PCNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PCNA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nuclear replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase delta processivity factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3616595..3617845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022425.3 → NP_596504.1  DNA polymerase delta processivity factor [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596504.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q03392
    Conserved Domains (1) summary
    TIGR00590
    Location:1 → 258
    pcna; proliferating cell nuclear antigen (pcna)
Nucleotide Protein
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Gene LinkOut

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