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hsp104 heat shock protein Hsp104 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540026, updated on 18-Sep-2024

Summary

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Official Symbol
hsp104
Official Full Name
heat shock protein Hsp104
Primary source
PomBase:SPBC16D10.08c
Locus tag
SPOM_SPBC16D10.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See hsp104 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3612265..3615269, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene histone deacetylase, Sirtuin family, NAD-dependent Sir2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA polymerase delta processivity factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast does not age under favorable conditions, but does so after stress. Coelho M, et al. Curr Biol, 2013 Oct 7. PMID 24035542, Free PMC Article
  2. The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. Sénéchal P, et al. PLoS One, 2009 Sep 11. PMID 19759825, Free PMC Article
  3. Fusion of protein aggregates facilitates asymmetric damage segregation. Coelho M, et al. PLoS Biol, 2014 Jun. PMID 24936793, Free PMC Article
  4. Dicer and Hsp104 function in a negative feedback loop to confer robustness to environmental stress. Oberti D, et al. Cell Rep, 2015 Jan 6. PMID 25543137
  5. Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress. Cabrera M, et al. Cell Rep, 2020 Feb 18. PMID 32075773

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsp104 and Hsp70-type chaperones are required for efficient degradation of Sdj1-L169P.
    Title: A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
  2. Hsp104 disaggregase is unable to propagate the [PSI] prion
    Title: The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein disaggregase activity EXP
Inferred from Experiment
more info
 PubMed 
enables misfolded protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular heat acclimation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular heat acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to misfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein refolding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein unfolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein unfolding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope HDA PubMed 
is_active_in nucleolar peripheral inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in protein aggregate center IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heat shock protein Hsp104

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3612265..3615269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022424.3 → NP_596503.1  heat shock protein Hsp104 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596503.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94641
    Conserved Domains (7) summary
    cd00009
    Location:184 → 345
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    TIGR03346
    Location:6 → 874
    chaperone_ClpB; ATP-dependent chaperone ClpB
    pfam02861
    Location:98 → 148
    Clp_N; Clp amino terminal domain, pathogenicity island component
    pfam07724
    Location:614 → 776
    AAA_2; AAA domain (Cdc48 subfamily)
    pfam10431
    Location:785 → 867
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    cl02376
    Location:374 → 456
    DUF2390; Protein of unknown function (DUF2390)
    cl23765
    Location:437 → 492
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
Nucleotide Protein
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