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chp2 heterochromatin (HP1) family chromodomain protein Chp2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540047, updated on 18-Sep-2024

Summary

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Official Symbol
chp2
Official Full Name
heterochromatin (HP1) family chromodomain protein Chp2
Primary source
PomBase:SPBC16C6.10
Locus tag
SPOM_SPBC16C6.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
clo2
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Genomic context

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See chp2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (4349995..4351244)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ER membrane O-mannosyltransferase Ogm4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly. Rahayu AF, et al. J Biochem, 2023 Sep 29. PMID 37400983
  2. The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast. Maksimov V, et al. PLoS One, 2018. PMID 30110338, Free PMC Article
  3. Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Leopold K, et al. Genes Dev, 2019 May 1. PMID 30808655, Free PMC Article
  4. HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin. Aygün O, et al. Nat Struct Mol Biol, 2013 May. PMID 23604080, Free PMC Article
  5. Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast. Sadaie M, et al. Mol Cell Biol, 2008 Dec. PMID 18809570, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest a two-step mechanism for SHREC's association with chromatin, in which Clr2 binds chromatin to form a platform for recruiting Clr1 and Clr3, while Chp2 may recruit Mit1 and additionally bind and stabilize the SHREC complex at the site. Stability of the Chp2 protein depended on the Clr3 protein's histone deacetylase activity.
    Title: The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast.
  2. findings uncover quantitative differences in how Swi6 and Chp2 interact with nucleosomal and non-nucleosomal ligands and qualitative differences in how their assembly on nucleosomes is regulated
    Title: Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.
  3. Swi6 and Chp2 exist in nonoverlapping complexes and make distinct contributions to silencing.
    Title: HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
  4. both Swi6 and Chp2 are required for the assembly of fully repressive heterochromatin, in which they play distinct, nonoverlapping roles
    Title: Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding EXP
Inferred from Experiment
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pericentric heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
located_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in subtelomeric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterochromatin (HP1) family chromodomain protein Chp2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4349995..4351244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023829.3 → NP_596808.1  heterochromatin (HP1) family chromodomain protein Chp2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596808.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42934
    Conserved Domains (2) summary
    smart00300
    Location:316 → 380
    ChSh; Chromo Shadow Domain
    cd00024
    Location:174 → 228
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
Nucleotide Protein
Heading Accession and Version

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