U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ndc80 protein Ndc80 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540097, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ndc80
Official Full Name
protein Ndc80
Primary source
PomBase:SPBC11C11.03
Locus tag
SPOM_SPBC11C11.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ndc10; tid3
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ndc80 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (3350827..3352972)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-BAR domain protein Imp2 Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tubulin-specific chaperone cofactor D Alp1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast. Chmielewska AE, et al. Cell Cycle, 2016. PMID 26900649, Free PMC Article
  2. Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast. Hsu KS, et al. Curr Biol, 2011 Feb 8. PMID 21256022, Free PMC Article
  3. The domain structure of centromeres is conserved from fission yeast to humans. Kniola B, et al. Mol Biol Cell, 2001 Sep. PMID 11553715, Free PMC Article
  4. The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment. Tang NH, et al. Mol Biol Cell, 2013 Apr. PMID 23427262, Free PMC Article
  5. Purification and characterisation of the fission yeast Ndc80 complex. Matsuo Y, et al. Protein Expr Purif, 2017 Jul. PMID 28502666, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
    Title: Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
  2. Ndc80 comprises two microtubule-interacting interfaces: the N-terminal region directly binds the microtubule lattice, while the internal loop interacts with the plus end of microtubules via Dis1/TOG.
    Title: Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast.
  3. Purification and characterization of the fission yeast Ndc80 complex has been described.
    Title: Purification and characterisation of the fission yeast Ndc80 complex.
  4. The Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1.
    Title: The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.
  5. An Ndc80 loop plays sequential roles in spindle-kinetochore attachment by connecting the Ndc80 complex to Dis1/TOG and Alp7/TACC-Alp14/TOG.
    Title: The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables kinetochore adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables kinetochore adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic centromere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid biorientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle attachment to meiosis I kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IC
Inferred by Curator
more info
  
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein Ndc80

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3350827..3352972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022313.3 → NP_596392.1  protein Ndc80 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596392.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10198
    Conserved Domains (3) summary
    COG5185
    Location:1 → 624
    HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
    pfam03801
    Location:73 → 220
    Ndc80_HEC; HEC/Ndc80p family
    cl20817
    Location:267 → 371
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials