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rap1 telomere-binding protein Rap1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540115, updated on 18-Sep-2024

Summary

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Official Symbol
rap1
Official Full Name
telomere-binding protein Rap1
Primary source
PomBase:SPBC1778.02
Locus tag
SPOM_SPBC1778.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
lot2
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Genomic context

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See rap1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (3098271..3100698)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene zuotin Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene NADH pyrophosphatase Neighboring gene guanyl-nucleotide exchange factor Lam2 Neighboring gene Spo4-Spo6 kinase complex regulatory subunit Spo6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA-DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast. Hu Y, et al. Genetics, 2019 Oct. PMID 31405990, Free PMC Article
  2. Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells. Maestroni L, et al. Nucleic Acids Res, 2020 Apr 6. PMID 31980821, Free PMC Article
  3. Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast. Irie H, et al. PLoS Genet, 2019 Aug. PMID 31454352, Free PMC Article
  4. The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope. Hu C, et al. Structure, 2019 Feb 5. PMID 30503780
  5. Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Greenwood J, et al. Nucleic Acids Res, 2018 Sep 28. PMID 29992245, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
    Title: The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
  2. our data demonstrate that Rap1-Bqt4-dependent telomere association to nuclear envelope preserves telomere integrity in post-mitotic cells, preventing telomeric transcription and recombination
    Title: Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells.
  3. We demonstrate that deletion of Rap1 is protective in this context, preventing the growth crisis that is otherwise triggered by degradation of telomeric R-loops in survivors with linear chromosomes. These findings suggest that upregulation of telomere-engaged TERRA, or altered recruitment of shelterin components, can support telomerase-independent telomere maintenance.
    Title: RNA-DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast.
  4. Fission yeast cells lacking shelterin components Taz1 or Rap1 showed higher gross chromosomal rearrangements (GCRs) rates compared to wild-type, accumulating large chromosome deletions. Study results highlight unappreciated functions of the shelterin components Taz1 and Rap1 in maintaining genome stability, specifically by preventing non-telomeric GCRs.
    Title: Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast.
  5. Rap1 is phosphorylated by CK2 at multiple sites, which promotes interactions with Bqt4 and Poz1. Phosphorylation at Ser496 was found to be crucial for both Rap1-Bqt4 and Rap1-Poz1 interactions.These mechanisms mediate proper telomere tethering to the NE and the formation of the silenced chromatin structure at chromosome ends.
    Title: Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.
  6. Telosome formation depends on the conserved telomeric proteins Taz1 and Rap1, and RNA. Rap1Delta telomeres lack detectable telosomes. Taz1 and Rap1 act together in organizing the telosome.
    Title: Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
  7. Whereas Rap1 hyper-phosphorylation observed in meiotic prophase does not have an apparent role in bouquet formation, the intrinsic negative charge of Rap1 is important for forming interactions with its binding partners.
    Title: Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation.
  8. fission yeast shelterin (shelterin subunits Poz1, Rap1 and Taz1 )maintains telomere length homeostasis by coordinating the differential arrival of leading (Polepsilon) and lagging (Polalpha) strand DNA polymerases at telomeres to modulate Rad3(ATR) association
    Title: Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.
  9. Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe
    Title: Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.
  10. it is proposed that the telomere dissociation from the nuclear envelope promoted by Rap1 phosphorylation is critical for the fidelity of chromosome segregation in closed mitosis
    Title: Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in meiotic attachment of telomeric heterochromatin to spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic attachment of telomeric heterochromatin to spindle pole body IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mitotic telomere tethering at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protection from non-homologous end joining at telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear telomere cap complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of shelterin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
telomere-binding protein Rap1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3098271..3100698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022207.3 → NP_596285.1  telomere-binding protein Rap1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596285.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q96TL7, Q9UTW1, Q9UU15
    Conserved Domains (4) summary
    cd11655
    Location:122 → 170
    rap1_myb-like; DNA-binding modules of yeast Rap1 and related proteins
    cd11670
    Location:645 → 693
    Sp_RAP1_RCT; C-terminal domain of S. pombe RAP1 protein
    pfam09197
    Location:494 → 603
    Rap1-DNA-bind; Rap1, DNA-binding
    pfam16589
    Location:1 → 103
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain
Nucleotide Protein
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